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EC number: 203-047-7 | CAS number: 102-69-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable well-documented report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- BASF-Test: The study was conducted according to an internal BASF method. A test group consisting of 5 animals/sex was treated by single injection into the peritoneal cavity. The animals were observed for mortality and for clinical symptoms of toxicity. They were weighed prior to treatment and thereafter, on day 3, 7 and day 13 post-treatment. At the end of the observation period of 14 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Tripropylamine
- EC Number:
- 203-047-7
- EC Name:
- Tripropylamine
- Cas Number:
- 102-69-2
- Molecular formula:
- C9H21N
- IUPAC Name:
- tripropylamine
- Test material form:
- other: emulsion
- Details on test material:
- - Name of test material (as cited in study report): Tri-n-propylamin
- Physical state: liquid
- Analytical purity: >= 98%
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: mean: females: 22.9 g, males: 24.0 g
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: 0.5% carboxmethyl cellulose and 2-3 drops of cremophor EL (v/v)
- Doses:
- 316, 215, 147, 121, 100, 68,1 and 46,4 µL/kg bw
(100 µL test substance corresponds to ca. 75 mg test substance calculated based on the density of the test substance) - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily observation, weighing was done on day 0, 3, 7 and 13
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 75 - 90 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: corresponds to 100 - 120 µL/kg bw calculated based on the density of the test substance
- Mortality:
- 316 µL/kg bw: all females and males died one hour after application of the test substance
215 µL/kg bw: 5/5 females and 3/5 males died one hour after application and 2 further males died 24 hours after application of the test substance
147 µL/kg bw: all females and 4/5 males died one hour after application of the test substance
121 µL/kg bw: all animals died one hour after application of the test substance
100, 68,1 and 46,4 µL/kg bw: no animal died within 14 days of observation - Clinical signs:
- dyspnoe, apathy, abdominal-lateral position, partly staggering, tremor, tonic-clonic convulsions, exsiccosis, partly exophthalmia, salivation, poor general state
- Body weight:
- Normal body weight gain was observed.
- Gross pathology:
- Neither intraabdominal precipitation of the substance nor conglutinations were observed.
Applicant's summary and conclusion
- Conclusions:
- An intraperitoneal LD50 of 75-90 mg/kg bw was established for rats.
- Executive summary:
The study was conducted according to an internal BASF method. A test group consisting of 5 animals/sex was treated by a single injection into the peritoneal cavity. The dose levels were: 316, 215, 147, 121, 100, 68,1 and 46,4 µL/kg bw. The animals were observed for mortality and for clinical symptoms of toxicity. They were weighed prior to treatment and thereafter, on day 3, 7 and day 13 post-treatment. At the end of the observation period of 14 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy. At dose levels of 100, 68,1 and 46,4 µL/kg bw, no animal died within 14 days of observation. The mortality was dose-dependent in animals of the other dose groups. The following clinical signs were noted: dyspnoea, apathy, abdominal-lateral position, partly staggering, tremor, tonic-clonic convulsions, exsiccosis, partly exophthalmia, salivation and poor general state. Normal body weight gain was observed in the surviving animals. Neither intraabdominal precipitation of the substance nor conglutinations were observed at gross pathology. An LD50 of 75 -90 mg/kg bw (corresponds to 100 -120 µL/kg bw) was established based on the density of test material.
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