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Diss Factsheets
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EC number: 203-047-7 | CAS number: 102-69-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- BASF-Test: The study was conducted according to an internal BASF method which in principle is comparable to the OECD Guideline 401.
A test group consisting of 5 animals/sex was treated by single gavage application with an aqueous solution of the test substance. The animals were observed for mortality and for clinical symptoms of toxicity. They were weighed prior to treatment and thereafter, on day 7 and day 13 post-treatment. At the end of the observation period of 14 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy. - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Tripropylamine
- EC Number:
- 203-047-7
- EC Name:
- Tripropylamine
- Cas Number:
- 102-69-2
- Molecular formula:
- C9H21N
- IUPAC Name:
- tripropylamine
- Details on test material:
- - Name of test material (as cited in study report): Tri-N-Propylamin
- Physical state: liquid
- Analytic purity: 98.7%
- Lot/batch No.: 47/89/60/88 89
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: DR. K . THOMAE GMBH, Biberach, Germany
- Age at study initiation: Young adult animals
- Weight at study initiation: male: 180 g (mean), female: 183 g (mean)
- Fasting period before study: 16 h
- Housing: 5 per cage
- Diet: Kliba Labordiaet 343, ad libitum
- Water: Tap water, ad libitum
- Acclimation period: at least 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24 °C
- Humidity (%): 30-70 %
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 4 and 40 %
- Justification for choice of vehicle: Test substance in insoluble in aqua dest.
MAXIMUM DOSE VOLUME APPLIED: 5 mL/kg bw - Doses:
- 200 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: at least once per day
- Frequency of weighing: days 0, 7 and 13
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 200 - 2 000 mg/kg bw
- Mortality:
- 200 mg/kg bw: no mortality occurred.
2000 mg/kg bw: 4 males and 5 females died within 1 h after application. A further male died within 24h after application. - Clinical signs:
- other: other: 200 mg/kg bw: no clinical signs 2000 mg/kg bw: Abdominal position, apathy, clonic convulsions, piloerection, salivation, staggering, tremor, twitching, poor general state.
- Gross pathology:
- Animals that died: General congestion.
Sacrificed animals: No pathologic findings noted.
Any other information on results incl. tables
Mortality:
Dose (mg/kg bw) | Gender | 1 h | day 1 | day 7 | day 13 |
200 | male | 0/5 | 0/5 | 0/5 | 0/5 |
200 | female | 0/5 | 0/5 | 0/5 | 0/5 |
2000 | male | 4/5 | 5/5 | 5/5 | 5/5 |
2000 | female | 5/5 | 5/5 | 5/5 | 5/5 |
Weight (g):
Dose (mg/kg bw) | Gender | day 0 | day 7 | day 13 | |
200 | male | 188 | 261 | 305 | |
200 | female | 187 | 220 | 231 | |
2000 | male | 171 | - | - | |
2000 | female | 179 | - | - |
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information according to the criteria in CLP, Annex I Criteria used for interpretation of results: EU
- Conclusions:
- An oral LD50 of 200-2000 was established for tripropylamine in rats. According to Regulation (EC) No 1272/2008, tripropylamine should be classified in Cat. 3 as an acute toxic substance by the oral route (H301 Toxic if swallowed).
- Executive summary:
The study was conducted according to an internal BASF method which in principle is comparable to the OECD Guideline 401. A test group consisting of 5 animals/sex was treated by single gavage application with an aqueous solution of the test substance. Two dose levels were used: 200 mg/kg bw and 2000 mg/kg bw. The animals were observed for mortality and for clinical symptoms of toxicity. They were weighed prior to treatment and thereafter, on day 7 and day 13 post-treatment. At the end of the observation period of 14 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy. No mortality occurred in animals treated with 200 mg/kg bw, while 4 males and 5 females died within 1 hour after application of 2000 mg/kg bw. No clinical signs were observed in animals in the low dose group (200 mg/kg bw); the animals gained weight. In the highest dose group (2000 mg/kg bw), abdominal position, apathy, clonic convulsions, piloerection, salivation, staggering, tremor, twitching and poor general state were observed. No pathological findings were noted at necropsy in sacrificed animals. In animals that died, general congestion was noted. LD50 is in the range of 200 -2000 mg/kg bw.
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