Butylethylmagnesium

Endpoint summary

Description of key information

The substance is corrosive, pyrophoric and reacts explosively with water

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records

Reference

Endpoint:

skin sensitisation: in vitro

Data waiving:

study technically not feasible

Justification for data waiving:

the study does not need to be conducted because the substance is spontaneously flammable in air or in contact with water or moisture at room temperature

Interpretation of results:

other: Waiver

Conclusions:

Corrosive. Flammable in air at room temperature. Thus, exposure of mammalian species to magnesium alkyls would notgenerate meaningful data, and no skin sensitization studies are required for this substance.

Executive summary:

Corrosive. Flammable in air at room temperature. Thus, exposure of mammalian species to magnesium alkyls would notgenerate meaningful data, and no skin sensitization studies are required for this substance.

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information:

Corrosive. Flammable in air at room temperature.

Magnesium alkyls are highly reactive both towards oxygen (air) and water as explained below. Almost all magnesium alkyls are infusible solids, however, because of difficulties in handling undiluted magnesium alkyl and the manufacturing processes used, they are exclusively marketed in liquid state (hydrocarbon solutions) and shipped under UN transport class 4.2 (substances liable to spontaneous combustion / pyrophoric liquids) or at least under class 4.3 (substances which in contact with water emit flammable gases). Thus, these in vitro tests are technically not feasible to conduct and are scientifically unjustified.

 

Magnesium alkyls in general are highly reactive towards oxidizing agents including molecular oxygen, thus reacting spontaneously in air. Neat magnesium alkyls also ignite spontaneously on contact to air and therefore are classified pyrophoric.

 

Reactions of magnesium alkyls with liquids are in some cases explosion like. Most prominent example is reaction with water, which liberates for short chain alkyls highly flammable gases within seconds (alkyl groups with five carbon atoms and less). But any substance bearing protic hydrogen react in similar fashion, like alcohols, acids (organic and inorganic), etc.

Migrated from Short description of key information:

Corrosive. Flammable in air at room temperature. According to the Annex VII Standard Information Requirements for REACH, as step 2 of the assessment of skin sensitization endpoint, in vivo testing for skin sensitization is required. A specific rule for adaptation for an in vivo skin sensitization test states that the study does not need to be conducted if - the available information indicates that the substance should be classified for skin sensitizatin or corrosivity; or - the substance is a strong acid (pH < 2.0) or base(pH> 11.5); or - the substance is flammable in air at room temperature.

Respiratory sensitisation

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information:

No data.  Substance is corrosive and flammable in air at room temperature.

Justification for classification or non-classification

Substance is corrosive and flammable in air at room temperature.