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Diss Factsheets
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EC number: 263-454-0 | CAS number: 62202-86-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Corrosive. Reactions of magnesium alkyls with liquids are in some cases explosion like. Most prominent example is reaction with water, which liberates for short chain alkyls highly flammable gases within seconds (alkyl groups with five carbon atoms and less). But any substance bearing protic hydrogen react in similar fashion, like alcohols, acids (organic and inorganic), etc.
Thus, exposure of mammalian species to magnesium alkyls would not generate meaningful data, and no acute toxicity studies are required for this substance.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Conclusions:
- Corrosive. Flammable in air at room temperature. Violent reaction with water. Exposure of mammalian species to magnesium alkyls would not generate meaningful data, and no acute oral toxicity studies are required for this substance.
- Executive summary:
Corrosive. Flammable in air at room temperature.Violent reaction with water. Exposure of mammalian species to magnesium alkyls would not generate meaningful data, and no acute oral toxicity studies are required for this substance.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Conclusions:
- Exposure of mammalian species to magnesium alkyls would not generate meaningful data, and no acute inhalation toxicity studies are required for this substance.
- Executive summary:
Exposure of mammalian species to magnesium alkyls would not generate meaningful data, and no acute toxicity studies are required for this substance.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Conclusions:
- Corrosive. Flammable in air at room temperature. Violent reaction with water. Exposure of mammalian species to magnesium alkyls would not generate meaningful data, and no acute dermal toxicity studies are required for this substance.
- Executive summary:
Corrosive. Flammable in air at room temperature.Violent reaction with water. Corrosive. Exposure of mammalian species to magnesium alkyls would not generate meaningful data, and no acute dermal toxicity studies are required for this substance.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
According to the Annex VII Standard Information Requirements for REACH, 8.5.1 of the assessment of the acute toxicity endpoint, an acute toxicity test by the oral route is required. A specific rule for adaptation for the acute toxicity study/ies states that the study(ies) do not need to be conducted if – the substance is classfied as corrosive to the skin.
Magnesium alkyls are highly reactive both towards oxygen (air) and water as explained below. Almost all magnesium alkyls are infusible solids, however, because of difficulties in handling undiluted magnesium alkyl and the manufacturing processes used, they are exclusively marketed in liquid state (hydrocarbon solutions) and shipped under UN transport class 4.2 (substances liable to spontaneous combustion / pyrophoric liquids) or at least under class 4.3 (substances which in contact with water emit flammable gases). Thus, these in vitro tests are technically not feasible to conduct and are scientifically unjustified.
Magnesium alkyls in general are highly reactive towards oxidizing agents including molecular oxygen, thus reacting spontaneously in air. Neat magnesium alkyls also ignite spontaneously on contact to air and therefore are classified pyrophoric.
Reactions of magnesium alkyls with liquids are in some cases explosion like. Most prominent example is reaction with water, which liberates for short chain alkyls highly flammable gases within seconds (alkyl groups with five carbon atoms and less). But any substance bearing protic hydrogen react in similar fashion, like alcohols, acids (organic and inorganic), etc.
Thus, exposure of mammalian species to magnesium alkyls would not generate meaningful data, and no acute oral toxicity studies are required for this substance.
Justification for classification or non-classification
A specific rule for adaptation for the acute toxicity studies states that the studies do not need to be conducted if - the substance is classified as corrosive to the skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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