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EC number: 222-598-4 | CAS number: 3547-33-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation was observed when 2-(octylthio)ethanol was applied to the skin of rabbits for 4 or 24 hours.
In the key eye irritation study, 2-(octylthio)ethanol was irritating to the eyes of rabbits, which was fully reversible within 7 days with the exception of one rabbit which exhibited very minimal conjunctival effects on Day 7. In another primary eye irritation study, irritation from the instillation of 2-(octylthio) ethanol into the eyes of rabbits was fully reversible within 14 days.
Key value for chemical safety assessment
Additional information
In a primary skin irritation study, 0.01 ml of undiluted 2 -(octylthio)ethanol was applied to the clipped skin of the belly of five albino rabbits for 24 hours. There was a definite erythema on all five rabbits. On the 14th day, the skin was normal and the application site could be identified only by the matted condition of the hair (Industrial Hygiene Foundation of America Inc., 1957). In another primary dermal irritation study, New Zealand white rabbits (3/sex) received 0.5 mL of 2-(octylthio) ethanol on the intact skin under 4-hour semi-occluded conditions. Treatment-related dermal reactions were erythema, edema and eschar formation; the average of the 4-, 24-, 48-, and 72-hour scores was 3.63(U.S. EPA, 1995).
2 -(octylthio)ethanol was not a skin irritant when tested in a human repeat insult patch test at a concentration of 6% in isopropanol (National Industrial Chemicals Notification and Assessment Scheme (1998).
The eye irritation was measured in rabbits exposed to 2 -(octylthiol)ethanol over a 24 hour period. Marked congestion, edema and exudation of the lids, congestion of the sclera, dull appearance of the cornea and slight irritation were observed. Fluorescein staining revealed necrosis of 75 -100% of the cornea in all dosed eyes. Following a 14 day observation period all eyes retained slight congestion of the iris and slight capillary injection of the lids and sclera, however, complete healing of the necrotic areas of the cornea were revealed with fluorescein staining. A dipilatory effect on the hair around the eyes leaving large denuded areas in some cases was also observed as an effect of the test substance. Due to the severity of the reaction of 0.5ml of undiluted sulfide it was difficult to evaluate and score the response, therefore, the test was repeated. After 24 hours, slight congestion and exudation of the lids and slight irritation were observed. Three of the five corneas were perfectly clear both before and after fluorescein staining. Two corneas were dull and stained with fluorescein. Following a 14 day observation period eyes were normal in all respects. These results indicate that 2 -(octylthiol)ethanol, even in small amounts, produces corneal necrosis of the rabbit eye. The fact that the corneas regenerate without opacities seems to indicate that the damage is superficial (Industrial Hygiene Foundation of America Inc., 1957).
In a key eye irritation study conducted similar to OECD Guideline 405, 2 -(octylthiol)ethanol was applied to the eyes of rabbits for a 24 hour period followed by a 7-day observation period. The mean iris and cornea scores were observed to be fully reversible within 4 days. Five of the six animals were observed to have fully reversible conjunctival effects by Day 7, with the exception of one animal which exhibited very minimal conjunctival effects on Day 7 (Hazleton Laboratories America Inc., 1982).
In another primary eye irritation study, 0.1 mL of 2-(octylthio) ethanol was instilled into the eyes of New Zealand white rabbits. There was mucus discharge in 1/6 rabbits; hazy cornea in 4/6 rabbits; and conjunctival irritation in all rabbits. Although no visible corneal opacity or iritis was noted, the positive reading noted in 5/6 rabbits during fluorescein dye examination indicated damage to the corneal epithelium. No ocular effects were seen by Day 14 (U.S. EPA, 1995).
Effect level: empty Endpoint conclusion: Adverse effect observed
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Classification proposal concerning skin irritation: Xi; R38. under DSD. Category 2 (H315) under GHS/CLP.
Classification proposal concerning eye irritation: Xi; R36. under DSD. Category 2 (H319) under GHS/CLP.
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