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EC number: 222-598-4 | CAS number: 3547-33-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 01-1957 to 03-1957
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Data included are from range-finding tests. Limited information on the test substance, animals tested/environmental conditions and details on examinations performed were provided. Animals were not fasted prior to testing. Complete necropsies were not performed for all animals. Not GLP.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 957
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: recommendations outlined by the National Safety Council
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- 2-(octylthio)ethanol
- EC Number:
- 222-598-4
- EC Name:
- 2-(octylthio)ethanol
- Cas Number:
- 3547-33-9
- Molecular formula:
- C10H22OS
- IUPAC Name:
- 2-(octylsulfanyl)ethan-1-ol
- Reference substance name:
- Ethanol, 2-(octylthio)-
- IUPAC Name:
- Ethanol, 2-(octylthio)-
- Reference substance name:
- 2-hydroxyethyl-n-octyl sulfide
- IUPAC Name:
- 2-hydroxyethyl-n-octyl sulfide
- Details on test material:
- - Name of test material (as cited in study report): 2-Hydroxyethyl-n-octyl sulfide
- Substance type: active
- Physical state: colorless liquid
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 108-127
- Fasting period before study: No
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other:
- Details on oral exposure:
- VEHICLE
- Amount of vehicle (if gavage): The test substance was diluted with Mazola and the concentrations were adjusted for reasonable accuracy in volume measurement so that at least 1 mL was administered at the lowest dosage. The low order of toxicity made it necessary to administer the undiluted test substance at the highest dosage.
- Justification for choice of vehicle: Preliminary tests indicated that the test substance was readily miscible with Mazola.
MAXIMUM DOSE VOLUME APPLIED: At least 1 mL was administered at the lowest dosage level. - Doses:
- 3.98, 7.95, 15.80, 31.60 g/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Weights on the animals were reported at the beginning of the study and after 14 days.
- Necropsy of survivors performed: yes; All fatalities were autopsied to exclude extraneous causes of death. Some survivors were autopsied for gross lesions.
- Other examinations performed: clinical signs, body weight and autopsies of gross lesions - Statistics:
- LD50 was estimated by Thompson's method of moving averages using the tables of Weil.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 8 530 mg/kg bw
- 95% CL:
- >= 6 040 - <= 12 050
- Mortality:
- All of the five rats dosed with the undiluted test substance at 31.60 g/kg died overnight. Three of the five rats on the 15.80 g/kg level died overnight; the two remaining rats died on the second day. Two rats on the 7.95 g/kg level died on the second day.
- Clinical signs:
- other: Immediately following the oral administration of the test substance, the rats on the three highest dosage levels were sick and ataxic. The surviving rats on the 7.95 g/kg and 3.98 g/kg levels were sluggish the first day, but recovered fully thereafter.
- Gross pathology:
- Autopsies of the surviviors revealed no gross lesions.
Applicant's summary and conclusion
- Conclusions:
- Based on these test conditions it has been determined that the LD50 is 8.53 g/kg for rats when exposed via oral gavage.
- Executive summary:
The LD50 of ethanol, 2-(octylthio) was determined by following the recommendations outlined by the National Safety Council. Five male rats were dosed by oral gavage at 3980, 7950, 15800 and 31600 mg/kg bw. Immediately following dosing, rats in the 31600 mg/kg bw group were sick and ataxic; all 5 rats died overnight. Of the 5 rats administered 15800 mg/kg bw, 3 died overnight; the 2 remaining rats died on the second day. Two rats in the 7950 mg/kg dose group died on the second day. The surviving rats in the 7950 and 3980 mg/kg groups were sluggish the first day, but recovered fully thereafter and showed good weight gains during the 14-day observation period. Autopsies of survivors revealed no gross lesions. The LD50 was 8530 mg/kg bw.
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