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EC number: 239-784-6 | CAS number: 15687-27-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
- Endpoint:
- fish early-life stage toxicity
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- April 1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Scientifically acceptable GLP guideline study; poster publication, acceptable for assessment. The reliability is also given in a draft study report by 'Wildlife Int. Ltd.'.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Ibuprofen: an early life-stage toxicity test with the Fathead minnow (Pimephales promelas)
- Author:
- Maack, G., Gallagher, S. P., Krueger, H. O., Leopold, A., Rechenberg, B.
- Year:
- 2 011
- Bibliographic source:
- Poster publication by the UBA (Umweltbundesamt)
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 210 (Fish, Early-Life Stage Toxicity Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Ibuprofen
- EC Number:
- 239-784-6
- EC Name:
- Ibuprofen
- Cas Number:
- 15687-27-1
- Molecular formula:
- C13H18O2
- IUPAC Name:
- 2-(4-isobutylphenyl)propanoic acid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Arcos Organics: lot 1) A0286876 (purity: 99.2%); lot 2) A0157934 (purity: 99.9%)
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: all treatments (from one replicate), samples of primary stock solutions,
- Sampling method: Days 0, 7, 14, 21, 28 and 33 (test termination), all samples were collected at mid-depth in the test chambers
- Sample storage conditions before analysis: not applicable, samples processed immediately for analysis
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: primary stock solution at 0.019 mg/mL; preparation of secondary stock solution (0.003, 0.0010, 0.0031, 0.010, 0.0313 mg/mL) by proportional dilution using the primary stock solution; preparation of stock solutions was performed 10 times during the exposure period
- Controls: negative control
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): not applicable
- Concentration of vehicle in test medium (stock solution and final test solution(s) or suspension(s) including control(s)):
- Evidence of undissolved material (e.g. precipitate, surface film, etc.): primary stock solution was clear and colorless with white precipitate flowting on the solution surface; secondary stock solutions were clear and colorless
Test organisms
- Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- TEST ORGANISM
- Common name: fathead minnow
- Source: Chesapeake Cultures, Inc., Hayes Virginia 23072, USA
METHOD FOR PREPARATION AND COLLECTION OF FERTILIZED EGGS
- Method of collection of fertilised eggs: Fathead minnow embryos (< 24 h old) were received on spawning substrate from source
POST-HATCH FEEDING
Live brine shrimp nauplii (Artemia sp.) three times per day during the first seven days of post-hatch. Thereafter, they were fed live brine shrimp nauplii three times per day on weekdays and at least two times per day on weekends. Fish were not fed for approximately 48 hours prior to the
termination of the test to allow for clearance of the digestive tracts before weight measurements were made.
Study design
- Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 33 d
- Remarks on exposure duration:
- 5-d embryo hatching period + 28 days post-hatch juvenile growth
Test conditions
- Hardness:
- control: 142±3 mg/L as CaCO3
highest test concentration: 138±2 mg/L as CaCO3 - Test temperature:
- 25 °C ± 1 °C
- pH:
- 8.0 to 8.2
- Dissolved oxygen:
- 7.2 mg/L (≥ 88%)
- Conductivity:
- control: 382 µmhos/cm
highest test concentration: 378±24 µmhos/cm - Nominal and measured concentrations:
- Nominal: 0.010, 0.032, 0.10, 0.32, 1.0 and 3.2 mg/L
Mean measured concentrations: 0 (control), 0.0091, 0.029, 0.092, 0.3, 0.93, 3.0 mg/L
Recovery: 91, 91, 92, 94, 93 and 94% - Details on test conditions:
- TEST SYSTEM
- Test vessel: Glass tanks (max. volume: 9 L)
- Fill volume: 7 L
- Aeration: yes
- Renewal rate of test solution (frequency/flow rate): 6 exchanges per day
- No. of fertilized eggs/embryos per vessel: 20
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16:8 (L:D)
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- hatching success
- time to hatch
- larval survival
- growth
POST-HATCH DETAILS
- Begin of post-hatch period: after 5 days (hatching period) - Reference substance (positive control):
- not specified
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 33 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 3 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- act. ingr.
- Basis for effect:
- number hatched
- Remarks:
- + time to hatch, larval mortality and growth
- Remarks on result:
- other: NOEC = highest tested concentration
- Duration:
- 33 d
- Dose descriptor:
- LOEC
- Effect conc.:
- > 3 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- act. ingr.
- Basis for effect:
- number hatched
- Remarks:
- + time to hatch, larval mortality and growth
- Details on results:
- As no effects could be observed up to the highest concentration tested (3 mg/L), the NOECs were set to be ≥ 3 mg/L and the LOEC values are derived to be > 3 mg/L.
Any other information on results incl. tables
Summary of hatching success, larval survival and growth parameters
Mean measured concentrations (mg/L) |
Hatching success (%) |
Survival to day 28 posthatch (%) |
Growth parameters at day 28 posthatch |
||
Mean total length ± SD (mm) |
Mean wet weight ± SD (mg) |
Mean dry weight ± SD (mg) |
|||
negative control |
100 |
76 |
24.2±0.66 |
108.3±2.88 |
21.9±0.92 |
0.0091 |
99 |
87 |
25.1±0.42 |
123.2±6.63 |
26.1±1.02 |
0.029 |
98 |
82 |
24.7±0.57 |
123.1±10.49 |
24.7±2.29 |
0.092 |
100 |
83 |
24.6±0.54 |
114.2±4.35 |
22.9±0.38 |
0.30 |
99 |
85 |
24.0±0.61 |
100.5±7.25 |
20.7±1.85 |
0.93 |
99 |
80 |
24.9±0.39 |
115.7±4.79 |
24.1±1.16 |
3 |
99 |
76 |
24.4±0.44 |
109.1±6.23 |
22.1±1.47 |
There
were no statistically significant differences for any parameter measured
in comparison to the negative control (p>
0.05).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.