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Diss Factsheets
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EC number: 239-784-6 | CAS number: 15687-27-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to other aquatic organisms
Administrative data
- Endpoint:
- toxicity to other aquatic vertebrates
- Remarks:
- thyroid hormone signaling and endocrine disruptor action in Rana (Lithobates) catesbeiana tadpoles
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- main objective of test set up was the investigation of effects by temperature. Exposure of living tadpoles to ibuprofen, effects (thyroid hormone signaling and endocrine disruptor action) studied in cell cultures
Data source
Reference
- Reference Type:
- publication
- Title:
- Influence of temperature on thyroid hormone signaling and endocrine disruptor action in Rana (Lithobates) catesbeiana tadpoles
- Author:
- S. Austin Hammond, Nik Veldhoen, Caren C. Helbing
- Year:
- 2 015
- Bibliographic source:
- General and Comparative Endocrinology 219: 6–15
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Investigation of the impact of temperature on the TH-induced gene expression programs of premetamorphic Rana (Lithobates) catesbeiana tadpoles following a single injection of 10 pmol/g body wet weight 3,30,5-triiodothyronine (T3). Gene transcript profiling was performed on back skin and tail fin cultured at either 5 or 24 °C following whole animal exposure
at nonpermissive (5 °C) temperature to T3 in the presence and absence of ibuprofen. - GLP compliance:
- no
Test material
Constituent 1
- Specific details on test material used for the study:
- no information given on purity
Test organisms
- Aquatic vertebrate type (other than fish):
- frog
- Test organisms (species):
- Rana catesbeiana
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 5 to 24 °C
Results and discussion
- Details on results:
- The transcript profiles of thra, rlk1, dio2, dio3, cirbp, sod, and cat were identical for T3 treated animals with or without added IBUPROFEN suggesting that the temperature effect was the overriding influence on these transcripts. However, T3-specific responses were detected for thibz, thrb, klf9 and cebp1 with the latter three showing indications of perturbation by IBUPROFEN. Both tail fin and back skin demonstrated an approximately 2-fold increase in thibz mRNAs at the nonpermissive temperature that was maintained regardless of the additional IBUPROFEN exposure (p <= 0.002). All cultured tissue samples from animals exposed to T3 ± IBUPROFEN showed augmentation of thibz mRNA levels of 3- to 5-fold-upon shift to the permissive temperature when compared to the low temperature condition. T3 + IBUPROFEN treatment was not different from T3 alone regarding hormone mediated elevation of thrb transcript levels. The T3-induced response at permissive temperature was not affected by IBUPROFEN in the back skin. At the nonpermissive temperature, a _2-fold elevation of klf9 in the back skin from animals coexposed to T3 and IBUPROFEN relative to T3 alone was observed (p <= 0.031).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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