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EC number: 219-348-1 | CAS number: 2421-28-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: guideline study; precedes establishment of GLP. Documentation is limited.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 963
- Report date:
- 1963
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 16 CFR 1500.42, Federal Hazardous Substances Act, USA
- Principles of method if other than guideline:
- Test material is placed in one eye of six albino rabbits, and the eyes are examined and graded for ocular irritation 24, 48 and 72 hours after administration.
- GLP compliance:
- no
- Remarks:
- preceeds establishment of GLP
Test material
- Reference substance name:
- Benzophenone-3,3':4,4'-tetracarboxylic dianhydride
- EC Number:
- 219-348-1
- EC Name:
- Benzophenone-3,3':4,4'-tetracarboxylic dianhydride
- Cas Number:
- 2421-28-5
- Molecular formula:
- C17H6O7
- IUPAC Name:
- 5-(1,3-dioxo-1,3-dihydro-2-benzofuran-5-carbonyl)-1,3-dihydro-2-benzofuran-1,3-dione
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: albino
- Details on test animals or tissues and environmental conditions:
- male and female.
Individually housed in metal cages suspended above the droppings.
Food and water were available ad libitum.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 3 mg applied to one eye.
- Duration of treatment / exposure:
- 7 days.
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- The untreated eye of each rabbit served as the control. Prior to application of the compound and again at the termination of the 7-day observation period, the eyes of each animal were examined with the use of 2% sodium fluorescein and a small-window ultraviolet, quartz, mercury pencil lamp. Other observations for eye irritation were made frequently on the day of application and again at 24, 48 and 72 hours, and at 4 and 7 days thereafter. Eye irritation was graded and recorded according the method of Draize in "Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics", 1959.
The treated eye was not washed.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 h and later
- Score:
- 0.1
- Max. score:
- 8
- Reversibility:
- fully reversible within: 24 h
- Irritant / corrosive response data:
- One rabbit showed mild irritation of the exposed eye one hour after instillation of the test material. This reaction appeared normal within 24 hours.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- 1,3-Isobenzofurandione, 5,5'-carbonylbis- (BTDA) was tested for eye irritation in albino rabbits, and evaluated for up to 7 days. The results indicate the substance is not irritating.
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