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Diss Factsheets
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EC number: 219-348-1 | CAS number: 2421-28-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Precedes establishment of guideline and GLP. Documentation is limited.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 963
- Report date:
- 1963
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- ; intact and abraded skin, 4 animals rather than 5 per dose group, evaluation scale for dermal toxicity includes erythema, edema, atonia, desquamation, coriaceous injury and fissuring.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Benzophenone-3,3':4,4'-tetracarboxylic dianhydride
- EC Number:
- 219-348-1
- EC Name:
- Benzophenone-3,3':4,4'-tetracarboxylic dianhydride
- Cas Number:
- 2421-28-5
- Molecular formula:
- C17H6O7
- IUPAC Name:
- 5-(1,3-dioxo-1,3-dihydro-2-benzofuran-5-carbonyl)-1,3-dihydro-2-benzofuran-1,3-dione
- Reference substance name:
- 291-348-1
- IUPAC Name:
- 291-348-1
- Test material form:
- solid: crystalline
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- other: albino, strain not given
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Individually housed in metal cages suspended above the droppings. Food and water were available ad libitum. At the end of the experiment, all rabbits were weighed, sacrificed by air embolization and necropsied. Rabbits that succumbed were necropsied also.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- ethanol
- Remarks:
- 25%
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 5 inches by 5 inches
- Type of wrap if used: The test material, as a paste, was distributed evenly over a piece of rubber dental dam, secured with adhesive tape and held in place with an elastic bandage.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Material was scraped from the abdomen skin; no washing was noted.
- Time after start of exposure:
TEST MATERIAL
- For solids, paste formed: yes; A semi-liquid mass was made with the powdered test material in 25% ethanol.
VEHICLE
- Concentration (if solution): 25% ethanol - Duration of exposure:
- 24 hours
- Doses:
- 50, 200, 794, 3160 mg/kg
- No. of animals per sex per dose:
- 4
- Control animals:
- no
- Details on study design:
- Skin was clipped with an electric clipper. The skin of 2 of the 4 rabbits in each group was abraded with a scalpel blade. Observation period: 14 days after removal of patch
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD0
- Effect level:
- > 3 160 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no deaths
- Mortality:
- no deaths
- Clinical signs:
- other: no signs of irritation or systemic toxicity
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- 1,3-Isobenzofurandione, 5,5'-carbonylbis- (BTDA) was studied in albino rabbits in an acute dermal lethality test similar to an OECD 402 protocol. No animals died during the 14-day test at the highest dose of 3160 mg/kg body weight.
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