Registration Dossier
Registration Dossier
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EC number: 810-495-2 | CAS number: 93452-03-0
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Read-across, OECD Guideline 203, non-GLP, key study, validity 2:
96h-LC50 (O. latipes) = 19 mg/L (nominal concentrations).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 19 mg/L
Additional information
To assess the short-term toxicity of the registered substance, METHYL CIS-3-OXO-2-PENTYL-1-CYCLOPENTANE ACETATE, to fish, one valid study is available.
This study (Yasuo, 1998), assessed as a key study, was performed on a read-across substance, METHYL 3-OXO-2-PENTYL-1-CYCLOPENTANE ACETATE (quality High Trans isomer), according to OECD Guideline 203 (1992) but not to GLP. This read-across substance is a mixture of two diastereomers, approximately 10% cis- and 90% trans-diastereomers which cis-diastereomer corresponds to the registered substance. Five series of the test substance (2.0, 4.2, 8.9, 19 and 40 mg/L) were exposed to Oryzias latipes during 96 hours, under semi-static conditions. A control and a solvent control were also performed as the test substance was dispersed in HCO-40. The concentrations of the test substance were not measured during the test but as the system was semi-static (daily complete renewal of the test solutions), it can be assumed that the test compound concentrations were maintained during the test (this was confirmed with the long-term toxicity study on Daphnia magna where nominal concentrations were relatively well maintained during static renewal conditions: 74 to 101% of nominal values).
The minimum concentration causing 100 % mortality within the period of the test was 40 mg/L. No mortality was observed in the Control and the Solvent Control during the test period. Abnormal swimming and the loss of swimming capacity were observed at 4.2 mg/L and the highest tested concentration. No abnormal responses were observed in the Control, the Solvent Control and at 2.0 mg/l. Therefore, the 96h-LC50 was determined to be 19 mg/L (95% CL: 8.9-40 mg/L) and the highest tested concentration without observed effect was determined to be 2.0 mg/L after 96 hours, based on nominal concentrations.
This supporting substance is considered adequate for read-across purposes based on similar physico-chemical properties and the same ready biodegradability potential between the registered substance and the analogue material used.
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