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EC number: 292-564-1 | CAS number: 90640-45-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The 21d NOEC reproduction for daphnia of 32 µg/L determined in an OECD 211 test using river water with N-C 12-14-alkyl-1,3-diaminopropane (CAS 90640-43-0) was used as a key value for the registered substance Amines, N-C16-22-alkyltrimethylenedi.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- NOEC
- Effect concentration:
- 32 µg/L
Additional information
Toxicity daphnia tests are not available for Amines, N-C16-22-alkyltrimethylenedi. Based on similarities of the environmental fate properties and the ecotoxicity data obtained in algae, Amines, N-C16-22-alkyltrimethylenedi can be grouped with the alkyl 1,3 diaminopropanes into the same category. In order to generate the worst-case scenario, all the OECD 211 tests done with various alkyl chain length diamines were taken into account and the lowest EC10 value was used as a key value for the registered substance Amines, N-C16-22-alkyltrimethylenedi.
The Daphnia magna Reproduction Test with natural river water (Semi-Static, 21 d) of N-C 12-14-alkyl-1,3-diaminopropane (CAS 90640 -43 -0) was conducted according to OECD 211 (Noack, 2008a). The test method was semi-static. All concentrations and control were analytically verified at four sampling dates with LC-MS/MS. Reproduction was the most sensitive endpoint. The effect levels (EC50, NOEC and LOEC) are therefore based on the reproduction output as the most sensitive effect. The NOECreproduction was 32.0 µg/L and the LOECreproduction was 100 µg/L determined after 21 days. The EC50 parental mortality was 179 µg/L determined after 21 days of exposure. The later value is used as worst-case acute EC50 for aquatic invertebrates in the hazard assessment in the absence of reliable acute data. The effects are expressed as nominal values because the tests were performed with river water as they are intended to be used in an evaluation of the environmental risks based on the bulk approach.
Daphnia reproduction tests have been performed in the same conditions with C18-unsatd-1,3-diaminopropane, CAS 7173 -62 -8 (Noack, 2008b) and C16 -18 and C18 -saturated-1,3 -diaminopropane, CAS 133779 -11 -0 (Noack, 2008c). For the C18 -unsatd, the nominal test item concentrations 320 and 1000 µg/L had a biologically significant effect on adult mortality (> 20 %) after 21 d of exposure and the EC50 for the adult mortality was calculated to be 290 µg/L. However, effects on reproduction did not occur.
For the C16 -18 and C18 -satd, the NOEC for adult mortality was 320 µg/L. 100% adult mortality was observed at the next higher concentration of 1000 µg/L. The EC50 for adult mortality is 566 µg/L. However, as for the C18 -unsatd, no effects on reproduction were observed up to 320 µg/L.
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