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EC number: 292-564-1 | CAS number: 90640-45-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Despite the fact that the log Kow was measured for Amines, N-C16-22-alkyltrimethylenedi- applying the most appropriate method according to the REACH guidance i.e. the slow stirring method (OECD 123), there is unfortunately no reliable relationship between the measured log Kow and BCF for this type of substances.
Regarding the diamines category, the worst case predicted BCF value is N-octadecylpropane-1,3-diamine (CAS 4253-76-3) according to BCFBAF predictions. Therefore, this calculation is considered in a worst-case approach to assess the bioaccumulation of the registered substance Amines, N-C16-22-alkyltrimethylenedi-. BCFBAF predictions on the constituent with the highest chain length (N-docosylpropane-1,3-diamine, CAS 15268-40-3) demonstrates that a higher bioaccumulation potential is not expected above C18 diamines.
Although the calculated BCF values predicted by the log Kow value of 7.69 (EPIsuite v4.0) for the unprotonated chemical form is clearly higher than the measured value of 1.5 (OECD 123), preference is given to base the calculated BCF on the measured log Kow value giving a calculated BCF value of 4.6. The calculated BCF value indicates that Amines, N-C16-22-alkyltrimethylenedi- have a low bioaccumulation potential.
The low calculated BCF is considered realistic as the fraction of unprotonated amines will be very low in the environment. The predicted BCF value could even be lower, as the calculation of the BCF is not taking into account metabolism of the compound, e.g. by fish and other aquatic organisms.
Key value for chemical safety assessment
- BCF (aquatic species):
- 4.6 L/kg ww
Additional information
Alkyl-1,3-diaminopropanes are readily biodegradable and it is therefore unlikely that these substances will accumulate in the food chain (BMF<1). Indeed, it can be expected that metabolism will occur in aquatic species like fish, the predicted BCF value could even be lower. In addition, performance of a standard aquatic exposure based OECD 305 test seems technically not feasible with these strongly sorbing easily degradable UVCB substances.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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