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REACH

Potassium carbamoylcarbamate

EC number: 247-728-7 | CAS number: 26479-35-6

Life Cycle description
Uses advised against

Ecotoxicological information

Sediment toxicity

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Administrative data

Link to relevant study record(s)

Description of key information

Long-term sediment toxicity testing is required when the results of the Chemical Safety Assessment (CSA) indicate that the substance and/or relevant degradation products may present a risk to benthic organisms. Cheng et al. (2005) has shown that potassium allophonate undergoes rapid hydrolysis in aqueous environments, forming urea (CAS No.: 57-13-6) exclusively. The aquatic ecotoxicological dataset is well-described and shows that it is of low toxicity to most aquatic organisms. Furthermore, due to the very high water solubility low adsorption potential for urea, very low exposure of sediment organisms is anticipated. Therefore, it is concluded that neither potassium allophonate nor urea present a risk to benthic organisms and testing for this endpoint is waived in accordance with Column 2 of Annex X of Regulation (EC) No. 1907/2006.

Key value for chemical safety assessment

Additional information

According to Column 2 of Annex X of Regulation (EC) No. 1907/2006, long-term sediment toxicity testing shall be proposed by the registrant if the results of the CSA indicates the need to investigate further the effects of the substance and/or relevant degradation products on sediment organisms. According to the read-across strategy document attached to this Chemical Safety Report (CSR) potassium allophonate quickly hydrolyses in the environment to form urea (CAS No.: 57 -13 -6) and, therefore, read-across to urea is used to assess ecotoxicity. The aquatic ecotoxicological dataset of urea is well-described and shows that it is of low toxicity to most aquatic organisms. Furthermore, due to its very high water solubility, 545 g/L at 25 deg C (Yalkowsky, 1989) and low adsorption potential, an organic carbon partition coefficient (Koc) of 0.037 to 0.064 L/kg (Hongprayoon et al., 1991), very low exposure of sediment organisms is anticipated. Therefore, it is concluded that neither potassium allophonate nor urea present a risk to benthic organisms and testing for this endpoint is waived in accordance with Column 2 of Annex X of Regulation (EC) No. 1907/2006.

References:

Cheng, G., Shapir, N., Sadowsky, M. J. and Wackett, L. P. 2005. Allophonate hydrolase, not urease, functions in bacterial cyanuric acid metabolism. Applied and Environmental Microbiology, 71(8): 4437 -45.

Hongprayoon, C., Patrick, W. H., Lindau, C. W., Bouldin, D. R., and Reddy, K. R. 1991. Urea Transformations in Flooded Soil Columns: I. Experimental Results. Soil Science Society of America Journal, 55: 1130 -4.

Yalkowsky, S. H. 1989. Arizona Database of Aqueous Solubility. College of Pharmacy, University of Arizona. Tucson, AZ.

Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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