Registration Dossier
Registration Dossier
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EC number: 244-169-0 | CAS number: 21049-70-7
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Since no studies on the chronic toxicity of 2-(methylamino)ethanol, compound with sulphur dioxide to fish are available, the endpoint has been covered with data from toxicity testing with sodium sulphite.
Reliable chronic toxicity data were reported in an early life stage study according to OECD guideline 210 using sodium sulphite (CAS 7757-83-7) as test substance [ECT, 2010]. Results show no adverse effects on hatching, post-hatch mortality, health, length and dry weight of surviving fish (Danio rerio). Consequently, a NOEC of >= 200.5 mg/L SO3 2- is proposed for this endpoint. It should be noted however, that the calculated NOEC for fish is almost a factor of 2 higher than the acute value of 149.6 mg SO3 2 -/L. This id due to the fact that oxygen depletion caused acute toxicity, whereas the test design of the ELS test (aerated test media) prevents mortality of exposed fish due to oxygen depletion. A more realistic long-term NOEC is therefore an acute exposure concentration, that:
- does not reduce the pH of the test media below a level causing adverse effects
- that does not reduce oxygen levels below unsafe levels at any point during the test.
An acute concentration of 84.1 mg SO3 2 -/L did not cause a pH-drop in the test medium (pH range 6.1 - 6.8). Evaluating the oxygen levels in the acute tests that were conducted with sulphite compounds, significant O2 -depletion upon addition of the test substance only occured at concentration levels higher than 50 mg SO3 2 -/L (test with K2SO3). Thus, based on these findings, a more realistic long-term NOEC of 50 mg SO3 2 -/L is put forward for the environmental classification and effects assessment of sulphite compounds.
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