Registration Dossier
Registration Dossier
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EC number: 254-372-6 | CAS number: 39236-46-9
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Report of a human volunteer study using a standard test method and including sufficient information to form a reliable conclusion.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
Materials and methods
- Type of study / information:
- Primary skin irritation study in human volunteers.
- Endpoint addressed:
- skin irritation / corrosion
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Single occluded patch test on human volunteers.
- GLP compliance:
- no
- Remarks:
- Pre-GLP study
Test material
- Reference substance name:
- 39326-46-9
- IUPAC Name:
- 39326-46-9
Constituent 1
Method
- Ethical approval:
- not specified
- Details on study design:
- Skin patch applied to each of 29 human volunteers: reactions at test sites scored 1 and 24h after patch removal.
- Details on exposure:
- 24h occluded application of aqueous test substance solutions (0.1, 1, 10%) to skin.
Results and discussion
- Results:
- No erythema or eschar was observed at any test site, in any of the 29 volunteers.
Applicant's summary and conclusion
- Conclusions:
- A complete absence of skin reaction to 24h occluded application of test substance (at concentrations up tp 20% on water) was seen in this study, leading to a conclusion that the substance was non-irritating.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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