Potassium dimethyldithiocarbamate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1983

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1983

Report date:

1983

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EPA OPP 81-1 (Acute Oral Toxicity)

GLP compliance:

yes

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Potassium dimethyldithiocarbamate

EC Number:

204-875-1

EC Name:

Potassium dimethyldithiocarbamate

Cas Number:

128-03-0

Molecular formula:

C3H7NS2.K

IUPAC Name:

potassium (dimethylcarbamothioyl)sulfanide

Details on test material:

- Name of test material (as cited in study report): Busan 85
- Physical state: Yellow-green coloured liquid
- Analytical purity: 50% KDDC
- Lot/batch No.: 2-7728
- Stability under test conditions: Stable for at least one year

Test animals

Species:

rat

Strain:

Fischer 344

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Charles River Laboratories, Kingston, New York
- Age at study initiation: 10-14 weeks
- Weight at study initiation: ♂: 170-220 g; ♀: 136-190 g
- Fasting period before study: yes

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 159, 182, 195, 209, 240, 275 mg/mL
- Amount of vehicle (if gavage): 10 mL/kg bw

Doses:

1585, 1820, 1950, 2089, 2399, 2754 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

Observations for death or overt signs of toxicity: 2 hours-intervals on the day of dosing, thereafter once daily for fourteen days
Body weights: prior to dosing, weekly thereafter and at sacrifice Necropsy: at scheduled sacrifice

Statistics:

LD50 was determined using Statistical Analysis System (SAS) PROBIT procedure

Results and discussion

Preliminary study:

5/5 males and 5/5 females died after administration of 5000 mg/kg.

Effect levels

Effect levels 1

Sex:

male/female

Dose descriptor:

LD50

Effect level:

2 030 mg/kg bw

95% CL:

1 884 - 2 184

Effect levels 2

Sex:

male

Dose descriptor:

LD50

Effect level:

2 196 mg/kg bw

95% CL:

1 888 - 2 485

Effect levels 3

Sex:

female

Dose descriptor:

LD50

Effect level:

1 867 mg/kg bw

95% CL:

1 713 - 2 054

Mortality:

see Table below

Clinical signs:

other: At doses above and including 2754 mg/kg bw, Busan 85 caused death in all animals, while all females died at doses above and including 1995 mg/kg bw. Some of the animals dying acutely were noted as having muscular spasm, tremor or convulsion. Other clinic

Gross pathology:

The major finding at necropsy in the acutely died animals included a reddish fluid in the stomach, reddening of the gastric mucosa and pulmonary congestion.