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EC number: 240-986-1 | CAS number: 16924-00-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- other: handbook data
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: A non GLP compliant study with little information on methodology or guidelines followed.
Data source
Reference
- Reference Type:
- publication
- Title:
- The Effects of Metals on the Chick Embryo: Toxicity and Production of Abnormalities in Development
- Author:
- Ridgeway L & Karnofsky D
- Year:
- 1 952
- Bibliographic source:
- Annals New York Academy of Sciences Pg. 203 - 215
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Dipotassium heptafluorotantalate
- EC Number:
- 240-986-1
- EC Name:
- Dipotassium heptafluorotantalate
- Cas Number:
- 16924-00-8
- Molecular formula:
- F7Ta.2K
- IUPAC Name:
- Tantalate(2-), heptafluoro-, potassium (1:2)
Constituent 1
Test animals
- Species:
- other: Chick embryo
- Strain:
- other: White Leghorn eggs
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Commercial supplier
- Age at study initiation: Embryo's were injected at either 4 or 8 days old
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Room temperature
Embroys were kept in incubation from study initiation to day 18, then all embryos were sacrificed.
Administration / exposure
- Route of administration:
- other: injection into 1 of 2 sites: yolk or CAM (chorioallantoic membrane)
- Vehicle:
- water
- Details on exposure:
- Injection volume - 0.05 -0.2 cc (cm³); occasionally yolks were injected with 0.3-0.4 cc (cm³)
Injection route - yolk at day 4; chorioallantoic membrane at day 8
Injection route preparation -
Yolk - a hole was drilled in the blunt end of the egg, the opening was sealed after exposure with melted paraffin.
CAM - a small window was cut in the shell directly over the membrane, post exposure the opening was sealed with Scotch tape.
Sample size - 6 - 10 eggs were injected at several dose levels either side of the estimated LD50. - Analytical verification of doses or concentrations:
- not specified
- Frequency of treatment:
- single dose
- Details on study design:
- Preliminary test:
Preliminary tests were performed on the 4 day embryo yolk sacs to identify an approximate LD50, then more precise testing was carried out to determine an accurate figure for the LD50.
The information from the preliminary test for yolk sacs was used to establish a staring point for the 8 day chorioallantoic membrane toxicity tests.
Observations:
Embryos were candled daily until the 18th day of incubation with dead embryos removed and examined. Occasionally embryos were sacrificed due to incubation reasons. All remaining embryos were sacrificed at day 18.
The following observations were recorded: abnormalities in skin, feathers, bone, brain and internal organs, The membranes and yolk were also inspected.
Results and discussion
Results: maternal animals
Maternal developmental toxicity
- Details on maternal toxic effects:
- Maternal toxic effects:not examined
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:no data
Details on embryotoxic / teratogenic effects:
The information on embryonic abnormalities or effects is not available for tantalum.
Effect levels (fetuses)
open allclose all
- Dose descriptor:
- other: LD50
- Effect level:
- ca. 20 other: Mgs/egg
- Based on:
- test mat.
- Basis for effect level:
- other: embryotoxicity
- Dose descriptor:
- other: LD50
- Effect level:
- ca. 36 other: (Microatoms/egg)
- Based on:
- test mat.
- Basis for effect level:
- other: embryotoxicity
- Dose descriptor:
- other: LD50
- Effect level:
- ca. 6.4 other: (Microatoms/egg)
- Based on:
- test mat.
- Basis for effect level:
- other: embryotoxicity
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of the test, the 4 day LD50 value of the test material when injected into the yolk was determined to be 20 mgs/egg. Additional LD 50 values were determined to be 51 microatoms/egg (4 day yolk), 36 microatoms/egg (8 day yolk) and 6.4 microatoms/egg (8 day chorioallantoic membrane(CAM)). The test material was shown to be more toxic to an embryo when injected into the CAM in comparison to exposure via the yolk.
- Executive summary:
Under the conditions of the test, the 4 day LD50 value of the test material when injected into the yolk was determined to be 20 mgs/egg. Additional LD 50 values were determined to be 51 microatoms/egg (4 day yolk), 36 microatoms/egg (8 day yolk) and 6.4 microatoms/egg (8 day chorioallantoic membrane(CAM)). The test material was shown to be more toxic to an embryo when injected into the CAM in comparison to exposure via the yolk. No information was given about any abnormalities or observations made during the study.
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