Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 240-986-1 | CAS number: 16924-00-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19th April 2006 to 15th June 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results. The study report was conclusive, done to a valid guideline and the study was conducted under GLP conditions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 2006
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Dipotassium heptafluorotantalate
- EC Number:
- 240-986-1
- EC Name:
- Dipotassium heptafluorotantalate
- Cas Number:
- 16924-00-8
- Molecular formula:
- F7Ta.2K
- IUPAC Name:
- Tantalate(2-), heptafluoro-, potassium (1:2)
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material (as cited in study report): Dikaliumheptafluorotantalat (Kaliumtantalfluorid)
- Substance type: White powder.
- Storage condition of test material: Kept tightly closed and dry at room temperature.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CD(SD)IGS BR
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland GmbH, D-97633 Sulzfeld.
- Age at study initiation: Approximately 8 weeks old at the time of administration.
- Weight at study initiation: Mean weight of the three dose groups (g): 182.3, 194.7, 180.0 . Ranging from 173 to 201 g
- Fasting period before study: Food was taken away the evening before the test material was administered then offered 3 hours after.
- Housing: Individually in Makrolon cages type lll (39 cm x 23 cm x 18 cm). Wire mesh lids. Sanitation once weekly.
- Diet: Altomin 1324 forte ad libitum
- Water: Tap water ad libitum
- Acclimation period: At least 5 days.
ENVIRONMENTAL CONDITIONS
- Temperature: 22.1°C
- Humidity: 52.6%
- Air changes: 12 per hr
- Photoperiod (hrs dark / hrs light): 12 hrs of artificial light/12 hrs darkness
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Justification for choice of vehicle: The test material hydrolyses in water.
- Amount of vehicle (if gavage): The exact amount was calculated based on the individual animals weight at the time of exposure.
MAXIMUM DOSE VOLUME APPLIED: 10mL/kg body weight.
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: No prior information on oral toxicity was available for the test substance, therefore a starting dose of 300 mg/kg bw was chosen as a starting point. - Doses:
- Dose 1: 300 mg/kg bw
Dose 2: 300 mg/kg bw
Dose 3: 2000 mg/kg bw - No. of animals per sex per dose:
- 3 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: clinical observations were performed 0-0.5, 0.5-1, 1-2, 2-4, and 4-6 hours after administration, then once a day for 14 days.
- Frequency of observations and weighing: Body weight observations were performed before administration, 7 and 14 days post administration.
- Necropsy of survivors performed: Deceased and sacrificed animals were subjected to necropsy being dissected and examined macroscopically including gross pathological examination to identify target organs.
- Other examinations performed: clinical observations included but were not limited to changes in skin, fur, eyes, the occurrence of secretions and excretions, autonomic activity, changes in gait, posture and the presence of convulsions.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 300 - < 500 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No reliability limits given
- Mortality:
- All animals in dose group 1 and 2 (300 mg/kg body weight) survived until the scheduled termination of the study. All animals in dose group 3 died on the day of administration of the test material. An overview of mortality and clinical observations can be seen in table 2 in the field " Any other information on results incl. tables".
- Clinical signs:
- other: Only high dose animals were affected. The findings, with an onset shortly after the administration and lasting until death, were: Autonomous nervous effects: increased lacrimation. Central nervous effects: unconsciousness. Other effects: cyanosis. Signs o
- Gross pathology:
- Abnormal findings were only present in deceased animals:
Glandular stomach, mucosa and small intestine: ulcera
Stomach and small intestine: blood in the lumen.
Any other information on results incl. tables
Table 2. Results
Dose (mg/kg) | Dose No. | No. of Animals | Prominent Findings | |||
exposed | affected | deceased | in life | post mortem | ||
300 | 1 | 3 | 0 | 0 | none | none |
300 | 2 | 3 | 0 | 0 | none | none |
2000 | 3 | 3 | 3 | 3 | signs of reduced well-being, increased lacrimation, cyanosis, unconsciousness. | glandular stomach, mucosa and small intestine, ulcera; stomach and small intestine, blood in the lumen. |
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the test, the test material caused gastrointestinal irritation when administered orally to rats. According to the test guidelines the LD50 was estimated to be between 300 – 500 mg/kg of body weight in rats. Therefore the test material is classified as harmful if swallowed under Directive 2001/59/EC.
- Executive summary:
In a GLP compliant acute oral toxicity study conducted in accordance with OCED Guideline 423 and EU method B.1 tris, the acute oral toxicity of the substance was determined using the fixed dose procedure. Female rats were subject to an oral dose of 300 or 2000 mg/kg of the test material by oral gavage and then were observed for 14 days. No signs of ill-health were observed in animals dosed at 300 mg/kg bw; however gastrointestinal irritation was observed in animals dosed at 2000 mg/kg bw.
Under the conditions of the study, the test material was considered to be harmful if swallowed. The test material requires classification as Harmful (Xn) with the associated risk phrase R22 “Harmful if swallowed" under Directive 2001/59/EC. Under Regulation 1272/2008 the test material requires classification as "Acute Tox. 4" with the associated hazard phrase "H302: Harmful if swallowed".
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.