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EC number: 700-903-6 | CAS number: 255830-15-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to a protocol similar to OECD 203 with GLP, however no analytical monitoring was carried out.
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- yes
- Remarks:
- lacks analytical monitoring and a range finding test
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: direct addition of test material to obtain each nominal concentration
- Evidence of undissolved material (e.g. precipitate, surface film, etc): none reported - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Source: Incontri con la natura,Cirie, Italy
- Length at study initiation (mean): 2.3 cm
- Weight at study initiation (mean): 0.345 g
- Method of breeding: not reported
- Feeding during test: no
ACCLIMATION
- Acclimation period: 2 months
- Acclimation conditions (same as test or not): same dilution water
- Type and amount of food: Mangime Principale JBL-JBL GmbH batch 301307 until 24 hours before start of the study
- Feeding frequency: daily
- Health during acclimation (any mortality observed): 0% after 7 days of acclimation - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- 40 mg/L as CaCO3 (dilution water)
- Test temperature:
- 20⁰C
- pH:
- range: 6.8 to 7.6 in the controls and 7.4 to 8.5 in exposure vessels. The pH decreased with time.
- Dissolved oxygen:
- range: 8.0 to 9.0 mg/l
- Nominal and measured concentrations:
- Nominal concentrations test substance: 0, 1000, 1200, 1440, 1728 and 2074 mg/l. (Equivalent to:
Nominal concentrations ATMP n oxide xK [43%]: 0, 430, 515, 620, 745 and 890 mg/L
Nominal concentration ATMP n oxide acid [27%]: 0, 270, 325, 390, 465 and 560 mg/L) - Details on test conditions:
- TEST SYSTEM
- Test vessel: tanks
- Material, size, fill volume: plastic, 30x36x24 cm filled with 10 L dilution water
- Aeration: not reported
- Renewal rate of test solution (frequency): 24 hours
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: ca. 0.345 g/L
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: from the municipal main water system
- Metals and Pesticides: within the acceptance limits of water quality defined in EEC Directive 80/778
- Culture medium different from test medium: no
- Intervals of water quality measurement: daily
OTHER TEST CONDITIONS
- Adjustment of pH: the pH was adjusted at the start of the study in vessels to pH 6-8.5 with 37% HCl solution.
- Photoperiod: 12 to 16 hours light
- Light intensity: not reported
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : mortality was measured every 24 hours from the start of the study. Behavioural of physiological abnormalities were also recorded at the same time.
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 1.2
- Range finding study: not conducted - Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1 152 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 495 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Remarks:
- active salt
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Calculated by reviewer
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 310 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Remarks:
- active acid
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Calculated by reviewer
- Details on results:
- - Behavioural abnormalities: none observed
- Abnormal responses: none observed
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: none
- Effect concentrations exceeding solubility of substance in test medium: no - Reported statistics and error estimates:
- No details reported. LC50 values as active acid and active salt have been calculated by the reviewer from the reported LC50 value of the test material of 1152 mg/L.
- Sublethal observations / clinical signs:
Table 1. Cumulative mortality results.
Nominal concentrations TS (mg/L) # dead animals 24 h 48 h 72 h 96 h % mortality Control 0 0 0 0 0 1000 1 1 1 1 10 1200 0 0 2 5 50 1440 2 4 6 7 70 1728 1 5 7 8 80 2074 5 6 8 9 90 - Validity criteria fulfilled:
- yes
- Conclusions:
- 96 h LC50 values of 495 mg active salt/L, and 310 mg active acid/L (as calculated by the reviewer), have been determined for the effects of the test substance on the mortality of the freshwater fish Brachydanio rerio. Although 100% mortality was not recorded, it was possible to derive an LC50.
Reference
Description of key information
96 h LC50 310 mg active acid/L, Brachdanio rerio, (reliability 2, RBM 1991)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 310 mg/L
Additional information
A 96 h LC50 value of 495 mg active salt/L, and 310 mg active acid/L, has been determined for the effects of the test substance on the mortality of the freshwater fish Brachydanio rerio (RBM 1991). Although 100% mortality was not recorded, it was possible to derive an LC50. The study was conducted according to EC test method C.1, however no analytical monitoring was carried out. This is the only study available with the substance and has been selected as key.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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