Registration Dossier
Registration Dossier
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EC number: 609-106-7 | CAS number: 35249-89-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study results have been reported in a review and it was not possible to evaluate the original study.
Data source
Reference
- Title:
- Final report on the safety assessment of glycolic acid, ammonium, calcium, potassium, and sodium glycolates, methyl, ethyl, propyl, and butyl glycolates, and lactic acid, ammonium, calcium, potassium, sodium and tea-lactates, methyl, ethyl, isopropyl, and
- Author:
- Cosmetic Ingredient Review
- Year:
- 1 998
- Bibliographic source:
- International Journal of Toxicology, 17(Suppl. 1):1-3.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: methods of the Journal Oficiel de la République Française
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Glycollic acid
- EC Number:
- 201-180-5
- EC Name:
- Glycollic acid
- Cas Number:
- 79-14-1
- Molecular formula:
- C2H4O3
- IUPAC Name:
- glycol acid
- Reference substance name:
- 2-hydroxyacetic acid
- IUPAC Name:
- 2-hydroxyacetic acid
- Reference substance name:
- Glycolic acid
- IUPAC Name:
- Glycolic acid
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rabbit
Test system
- Vehicle:
- other: a face cream and 2 peeling products
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: dermic irritation index
- Score:
- 0.5
- Remarks on result:
- other: (15% glycolic acid in a face cream)
- Irritation parameter:
- other: dermic irritation index
- Score:
- 0.33
- Remarks on result:
- other: (25% glycolic acid in a peeling product)
- Irritation parameter:
- other: dermic irritation index
- Score:
- 0.38
- Remarks on result:
- other: (50% glycolic acid in a peeling product)
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Glycolic acid in the tested formulations resulted not irritating.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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