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EC number: 932-389-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study similar to guideline with minor restrictions and under GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- nine rabbits were used, in three of them the test item was washed out 20 seconds after instillation, scoring was performed according to Kay and Calandra
- GLP compliance:
- yes
Test material
- Reference substance name:
- Reaction mass of (R)-cyano(3-phenoxyphenyl)methyl rel-(1R,3R)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate and (R)-cyano(3-phenoxyphenyl)methyl rel-(1S,3S)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate
- EC Number:
- 932-389-6
- Molecular formula:
- C23H19ClF3NO3
- IUPAC Name:
- Reaction mass of (R)-cyano(3-phenoxyphenyl)methyl rel-(1R,3R)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate and (R)-cyano(3-phenoxyphenyl)methyl rel-(1S,3S)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Hacking & Churchill, Abbotts Ripton Rd., Wyton, Nr Huntingdon, Cambridgeshire, UK
- Age at study initiation: 77-119 d
- Weight at study initiation: 2.0-3.5 kg
- Housing: individually in aluminium sheet cages (605x490x455 mm)
- Diet (e.g. ad libitum): Labsure CRB Rabbit Diet ad libitum
- Water (e.g. ad libitum): tap water ad libitum
- Acclimation period: at least 3 weeks
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18±1°C
- Humidity (%): approximately 65%
- Air changes (per hr): 10-20
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.1 mL undiluted test material
- Duration of treatment / exposure:
- 6/9 animals: the test item was not removed
3/9 animals: the test item was washed out 20 seconds after instillation - Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 9 animals
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): in 3 of 9 animals, the test item was washed out with lukewarm tap water for 1 minute
- Time after start of exposure: 20 seconds after instillation
SCORING SYSTEM:
Eye effects: according to Kay JH, Calandra JC, J Soc Cosmet Chem. 1962, 13:6
Pain: 5 stage scoring system
0 - No pain (No response)
1 - Practically no initial pain (A few blinks only; normal within 1-2 min)
2 - Slight initial pain (Rabbit blinks and tries to open eye, but the reflex closes it)
3 - Moderate initial pain (Rabbit holds eye shut and puts pressure on lids; may rub eye with paw)
4 - Severe initial pain (Rabbit holds eye shut vigorously; may squeal)
5 - Very severe initial pain (Rabbit holds eye shut vigorously; may squeal, claw at eye, jump and try to escape)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- other: 1-2h
- Score:
- 26
- Max. score:
- 110
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- 24 h
- Score:
- 24
- Max. score:
- 110
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- 48 h
- Score:
- 11
- Max. score:
- 110
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- 72 h
- Score:
- 9
- Max. score:
- 110
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- other: day 4
- Score:
- 4
- Max. score:
- 110
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- 7 d
- Score:
- 0
- Max. score:
- 110
- Reversibility:
- fully reversible
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- other: 1-2h
- Score:
- 29
- Max. score:
- 110
- Reversibility:
- fully reversible within: 3 days
- Remarks on result:
- other: irrigation group
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- 24 h
- Score:
- 19
- Max. score:
- 110
- Reversibility:
- fully reversible within: 3 days
- Remarks on result:
- other: irrigation group
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- 48 h
- Score:
- 3
- Max. score:
- 110
- Reversibility:
- fully reversible within: 3 days
- Remarks on result:
- other: irrigation group
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 110
- Reversibility:
- fully reversible
- Remarks on result:
- other: irrigation group
- Irritant / corrosive response data:
- Conjunctivitis, corneal opacity and iritis were observed in all animals but were fully reversible within 7 days. Conjunctivitis, corneal opacity and iritis were noticeably less prominent in rabbits receiving irrigation with water and were also fully reversible within 3 days. Many of the animals showed signs of convoluted and sensitive eyelids. In some animals the lids were thickened with crusting from the discharge early in the study. However, none of these abnormalities was observed at day 7.
- Other effects:
- Instillation of cyhalothrin into the rabbit eye caused practically no initial pain in seven animals and slight to moderate initial pain in the other two (1-2/3 on a 0-5 scale).
Any other information on results incl. tables
Table 1: Mean eye irritation scores after cyhalothrin instillation in the rabbit eye (unwashed)
|
Max score |
Group mean score |
|||||
1-2 h |
day 1 |
day 2 |
day 3 |
day 4 |
day 7 |
||
Cornea |
80 |
8 |
10 |
5 |
5 |
2 |
0 |
Iris |
10 |
4 |
3 |
2 |
1 |
1 |
0 |
Conjunctiva |
20 |
14 |
11 |
4 |
3 |
1 |
0 |
Total |
110 |
26 |
24 |
11 |
9 |
4 |
0 |
Values are means of 6 animals and rounded to the nearest whole number
Table 2: Mean eye irritation scores after cyhalothrin instillation in the rabbit eye (washed out after 20 sec)
|
Max score |
Group mean score |
|||||
1-2 h |
day 1 |
day 2 |
day 3 |
day 4 |
day 7 |
||
Cornea |
80 |
10 |
7 |
0 |
0 |
0 |
0 |
Iris |
10 |
5 |
3 |
0 |
0 |
0 |
0 |
Conjunctiva |
20 |
14 |
9 |
3 |
0 |
0 |
0 |
Total |
110 |
29 |
19 |
3 |
0 |
0 |
0 |
Values are means of 3 animals and rounded to the nearest whole number
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- The study is considered to be reliable with restrictions.
- Executive summary:
The eye irritating properties of cyhalothrin were assessed in an in vivo test similar to OECD Guideline 405 with slight modifications and under GLP. The scoring of eye effects was performed according to Kay and Calandra. In three rabbits, the test item was removed 20 seconds after instillation by irrigation with water.
Conjunctivitis, corneal opacity and iritis were observed in all animals but were fully reversible within 7 days. Conjunctivitis, corneal opacity and iritis were noticeably less prominent in rabbits receiving irrigation with water and were fully reversible within 3 days. Convoluted and sensitive eyelids were observed in many animals as well as thickened lids with crusting from discharge.
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