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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The data are available from ECHA as data older than 12 years of age and no longer protected. The registrant has been unable to varify the quality of the original data

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1993

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 471 (Bacterial Reverse Mutation Assay)
GLP compliance:
yes
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
1,6-hexanediyl-bis(2-(2-(1-ethylpentyl)-3-oxazolidinyl)ethyl)carbamate
EC Number:
411-700-4
EC Name:
1,6-hexanediyl-bis(2-(2-(1-ethylpentyl)-3-oxazolidinyl)ethyl)carbamate
Cas Number:
140921-24-0
Molecular formula:
C32H62N4O6
IUPAC Name:
2-[3-(heptan-3-yl)-1,2-oxazolidin-2-yl]ethyl N-{6-[({2-[3-(heptan-3-yl)-1,2-oxazolidin-2-yl]ethoxy}carbonyl)amino]hexyl}carbamate

Method

Species / strain
Species / strain / cell type:
S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
Metabolic activation:
with and without
Metabolic activation system:
Rat liver induced with Aroclor 1254
Test concentrations with justification for top dose:
Concentration range in the main test (with metabolic activation): 8 ... 5000 μg/plate
Concentration range in the main test (without metabolic activation): 8 ... 5000 μg/plate
Vehicle / solvent:
Ethanol

Results and discussion

Test results
Species / strain:
S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
no cytotoxicity
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Remarks on result:
other: all strains/cell types tested
Remarks:
Migrated from field 'Test system'.

Any other information on results incl. tables

Metabolic with activation

Test                  other:maintestsystem

Cytotoxicity    yes (>= 1000 pg/piate)

Species/strain       other:asspecified above

Metabolic without activation

Test                other:maintest

system

Cytotoxicity yes (>= 1000 pg/plate)

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative

The substance is considered to be non mutagenic
Executive summary:

The mutagenicity of the substance has been assessed by the reverse mutation of bacterial salmonella strains. Both with and without metabolic activation, the substance induced no mutagenic response. The substance is, therefore, considered to be non-mutagenic.