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EC number: 688-501-6 | CAS number: 21700-31-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30.9.-16.10.2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 1,1,1,2,3-pentachloropropane
- EC Number:
- 688-501-6
- Cas Number:
- 21700-31-2
- Molecular formula:
- C3H3Cl5
- IUPAC Name:
- 1,1,1,2,3-pentachloropropane
- Details on test material:
- - Name of test material (as cited in study report): 1,1,1,2,3-pentachloropropane
- Substance type: organic
- Physical state: liquid
- Analytical purity: 99.940 % (w/w)
- Impurities (identity and concentrations): chlorinated hydrocarbons - 0.048 % (w/w)
- Lot/batch No.: 2-750
- Expiration date of the lot/batch: august 2014
- Storage condition of test material: dry place at room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: breeding farm VELAZ, s.r.o., Koleč u Kladna, Czech Republic,
- Age at study initiation: 8-12 weeks at the time application
- Weight at study initiation: 182.8 - 221.4 g
- Fasting period before study: 20 hours
- Housing: animal room with monitoring conditions – 3 animals of one sex in one plastic breeding cage Velaz T4
- Diet (e.g. ad libitum): ST 1 BERGMAN – standard pelleted diet ad libitum
- Water (e.g. ad libitum): drinking tap water ad libitum
- Acclimation period: min. 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22±3°C (permanently monitoring)
- Humidity (%): 30 - 70 % (permanently monitoring)
- Photoperiod (hrs dark / hrs light): 12-hour light/12 hour dark
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle and amount of vehicle (if gavage): Concentration of the test material was chosen so that the dose volume was 1mL/100 g of animal body weight.
- Lot/batch no. (if required): 5211201 - Doses:
- 300 mg/kg body weight
2000 mg/kg body weight - No. of animals per sex per dose:
- 3 animals / sex/ dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of clinical observations: daily
- Frequency of weighing: before application, 8th day and before euthanasia of animals
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross necropsy.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - <= 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 2000 mg/kg: 1 animal died and 2 animals were humanely sacrificed by reason of moribund condition
300 mg/kg: no mortality - Clinical signs:
- other: see Table No. 2
- Gross pathology:
- Animal No.: 1 (2000 mg/kg) - anaemic skin, fur stained by urine, cachexy, reddish brown lacrimation and discharge from nostril, endophtalmus, hyperemia of stomach with red punctiform foci (diameter 0,5 mm), liver marked structure, thoracic and abdominal cavity smelled by the test substance.
Animal No.: 2 (2000 mg/kg) - anaemic skin, fur stained by urine, cachexy, reddish brown lacrimation and discharge from nostril, endophtalmus, hyperemia of stomach with red punctiform foci (diameter 0,5 mm), liver marked structure, thoracic and abdominal cavity smelled by the test substance.
Animal No.: 3 (2000 mg/kg) - anaemic skin, fur stained by urine, cachexy, reddish brown lacrimation and discharge from nostril, endophtalmus, hyperemia of stomach with red punctiform foci (diameter 0,5 mm), liver marked structure and anaemic, thoracic and abdominal cavity smelled by the test substance.
Animals No.: 4 - 9 (300 mg/kg) - without pathologic changes
Any other information on results incl. tables
Table No. 1: Body weight
Dose (mg/kg) (Step No.) |
Animal No. |
Body weight (g) |
||
Before |
2 days |
15 days |
||
2000 (1) |
1 |
213.7 |
204.8 |
- |
2 |
197.9 |
192.6 |
- |
|
3 |
182.8 |
176.1 |
- |
|
300 (2) |
4 |
221.4 |
249.4 |
261.4 |
5 |
191.1 |
211.9 |
220.2 |
|
6 |
202.4 |
224.3 |
233.0 |
|
300 (3) |
7 |
204.8 |
239.9 |
252.2 |
8 |
190.8 |
215.3 |
227.0 |
|
9 |
194.0 |
226.6 |
236.1 |
Table No. 2: Clinical observation
Dose (mg/kg) |
Animal No. |
Death after application |
Observed changes |
2000 |
1 |
Yes |
30 minutes: piloerection, gibbous posture, apathy, lurch walking and pulling pelvis legs, no response to stimuli, bradypnoea 3 hours:piloerection, gibbous posture, apathy, lurch walking and pulling pelvis legs, no response to stimuli, bradypnoea 2ndday morning:anaemic skin, fur stained by urine, anaemic visible mucouse membrane, abdominal position and apathy, immobility, reddish brown discharge from nostril and lacrimation |
2000 |
2 |
Humanely sacrificed (2ndday) |
30 minutes: piloerection, gibbous posture, apathy, lurch walking and pulling pelvis legs, no response to stimuli, bradypnoea 3 hours:piloerection, gibbous posture, apathy, lurch walking and pulling pelvis legs, no response to stimuli, bradypnoea 2ndday morning:anaemic skin, fur stained by urine, anaemic visible mucouse membrane, abdominal position and apathy, immobility, reddish brown discharge from nostril and lacrimation, no response to stimuli, bradypnoe |
2000 |
3 |
Humanely sacrificed (2ndday) |
30 minutes: piloerection, gibbous posture, apathy, lurch walking and pulling pelvis legs, no response to stimuli, bradypnoea 3 hours:piloerection, gibbous posture, apathy, lurch walking and pulling pelvis legs, no response to stimuli, bradypnoea 2ndday morning:anaemic skin, fur stained by urine, anaemic visible mucouse membrane, abdominal position and apathy, immobility, reddish brown discharge from nostril and lacrimation, no response to stimuli, bradypnoea |
300 |
4 |
No |
30 minutes: piloerection, gibbous posture 3 hours:piloerection, gibbous posture, decreased reaction to stimuli,reddish brown lacrimation 2ndday morning: reddish brown discharge from nostril 2ndday afternoon -14thday:no clinical signs of intoxication |
300 |
5 |
No |
30 minutes: piloerection, gibbous posture 3 hours:piloerection, gibbous posture, decreased reaction to stimuli,reddish brown lacrimation 2ndday morning: reddish brown discharge from nostril 2ndday afternoon -14thday:no clinical signs of intoxication |
300 |
6 |
No |
30 minutes: piloerection, gibbous posture 3 hours:piloerection, gibbous posture, decreased reaction to stimuli,reddish brown lacrimation 2ndday morning: reddish brown discharge from nostril 2ndday afternoon -14thday:no clinical signs of intoxication |
300 |
7 |
No |
30 minutes: piloerection, gibbous posture 3 hours:piloerection, gibbous posture, decreased reaction to stimuli,reddish brown lacrimation 2ndday morning: reddish brown discharge from nostril 2ndday afternoon -14thday:no clinical signs of intoxication |
300 |
8 |
No |
30 minutes: piloerection, gibbous posture 3 hours:piloerection, gibbous posture, decreased reaction to stimuli,reddish brown lacrimation 2ndday morning: reddish brown discharge from nostril 2ndday afternoon -14thday:no clinical signs of intoxication |
300 |
9 |
No |
30 minutes: piloerection, gibbous posture 3 hours:piloerection, gibbous posture, decreased reaction to stimuli,reddish brown lacrimation 2ndday morning: reddish brown discharge from nostril 2ndday afternoon -14thday:no clinical signs of intoxication |
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test substance administered at the dose of 2000 mg/kg caused death of one animal and two animals were humanely sacrificed by reason of moribund condition on the 2nd day morning.
The clinical signs of intoxication - piloerection, gibbous posture, apathy, lurch walking and pulling pelvis legs, no response to stimuli, bradypnoea were detected in all animals 30 minutes and 3 hours after application.
The further clinical signs of intoxication were observed 2nd day after application: anaemic skin (piloerection disappeared), fur stained by urine, anaemic visible mucouse membrane, abdominal position and apathy instead of gibbous posture, immobility (instead of lurch walking and pulling pelvis legs), no response to stimuli, reddish brown discharge from nostril and lacrimation, bradypnoe.
During pathological examination the following changes were observed in all animals: anaemic skin, fur stained by urine, cachexy, reddish brown lacrimation and discharge from nostril, endophtalmus, hyperemia of stomach with red punctiform foci (diameter 0,5 mm), liver marked structure in all animals and anaemic in one female. The thoracic and abdominal cavity of all three animals smelled by the test substance.
The test substance administered at the dose of 300 mg/kg caused no death in any of two administered groups of females (group No. 2 and No. 3).
Clinical signs of intoxication (piloerection, gibbous posture) were observed 1st day of the study in all six animals. The reddish brown lacrimation and decreased response to stimuli were observed 3 hours after application. The reddish brown discharge from nostril was observed 2nd day morning in all six animals. No pathologic macroscopic changes were diagnosed during pathological examination.
According to the study results the value of LD50 of the test substance, 1,1,1,2,3 - Pentachloropropane, for female rats is in the range > 300 mg/kg to ≤ 2000 mg/kg. - Executive summary:
The aim of the study was to investigate acute toxic effects of the test substance 1,1,1,2,3 - Pentachloropropane, after a single oral administration to Wistar rats.
The testing was performed according to the Method B.1 tris: Acute Oral Toxicity - Acute Toxic Class Method, Council Regulation (EC) No.440/2008, published in O.J. L 142, 2008 and OECD Test Guideline No. 423: Acute Oral Toxicity – Acute Toxic Class Method (Adopted 17th December 2001).
The test substance was administered in a single dose as solution in vehicle (olive oil), given orally via gavage to female Wistar rats. The dosing was performed sequentially in three groups of three females: group No. 1 (first step) using the starting dose of 2000 mg/kg body weight, group No. 2 (second step) and group No. 3 (third step) using a dose of 300 mg/kg body weight. The volume of administered solution was 1 ml/100 g body weight of animals.
The test substance administered at the dose of 2000 mg/kg caused death of one animal and two animals were humanely sacrificed by reason of moribund condition on the 2nd day morning.
The clinical signs of intoxication - piloerection, gibbous posture, apathy, lurch walking and pulling pelvis legs, no response to stimuli, bradypnoea were detected in all animals 30 minutes and 3 hours after application.
The further clinical signs of intoxication were observed 2nd day after application: anaemic skin (piloerection disappeared), fur stained by urine, anaemic visible mucous membrane, abdominal position and apathy instead of gibbous posture, immobility (instead of lurch walking and pulling pelvis legs), no response to stimuli, reddish brown discharge from nostril and lacrimation, bradypnoea.
During pathological examination the following changes were observed in all animals: anaemic skin, fur stained by urine, cachexy, reddish brown lacrimation and discharge from nostril, endophtalmus, hyperemia of stomach with red punctiform foci (diameter 0,5 mm), liver marked structure in all animals and anaemic in one female. The thoracic and abdominal cavity of all three animals smelled by the test substance.
The test substance administered at the dose of 300 mg/kg caused no death in any of two administered groups of females (group No. 2 and No. 3).
Clinical signs of intoxication (piloerection, gibbous posture) were observed 1st day of the study in all six animals. The reddish brown lacrimation and decreased response to stimuli were observed 3 hours after application. The reddish brown discharge from nostril was observed 2nd day morning in all six animals. No pathologic macroscopic changes were diagnosed during pathological examination.
According to the study results the value of LD50 of the test substance, 1,1,1,2,3 - Pentachloropropane, for female rats is in the range > 300 mg/kg to ≤ 2000 mg/kg.
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