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EC number: 252-328-0 | CAS number: 35037-73-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Seven or eight groups of 10 male and 10 female young adult Wister rats (weight 160 - 200 g) each received per gavage a single dose of 100, 1000, 1500, 1750, 2000, 2500, 3000, or 5000 mg/kg bw (male rats) and 100, 500, 1000, 1250, 1500, 2000, or 2500 mg/kg bw (female rats) 4-trifluormethoxyphenyl isocyanate. The animals were observed for mortality and clinical signs through day 14. A gross pathological examination was performed on animals which died during the observation period or were killed after termination of the study.
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- p-(trifluoromethoxy)phenyl isocyanate
- EC Number:
- 252-328-0
- EC Name:
- p-(trifluoromethoxy)phenyl isocyanate
- Cas Number:
- 35037-73-1
- Molecular formula:
- C8H4F3NO2
- IUPAC Name:
- 1-isocyanato-4-(trifluoromethoxy)benzene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: acetone/oil 2:10
- Doses:
- male rats: 100, 1000, 1500, 1750, 2000, 2500, 3000, or 5000 mg/kg bw
female rats: 100, 500, 1000, 1250, 1500, 2000, or 2500 mg/kg bw - No. of animals per sex per dose:
- 10 animals /sex/dose
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 525 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 320 - <= 1 761
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 170 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 906 - <= 2 469
- Mortality:
- The corresponding mortality for male rats was 0% (100 mg/kg bw), 0% (1000 mg/kg bw), 0% (1500 mg/kg bw), 20% (1750 mg/kg bw), 60% (2000 mg/kg bw), 70% (2500 mg/kg bw), 80% (3000 mg/kg bw) and 90% (5000 mg/kg bw) respectively.
The corresponding mortality for female rats was 0% (100 mg/kg bw), 0% (500 mg/kg bw), 0% (1000 mg/kg bw), 20% (1250 mg/kg bw), 40% (1500 mg/kg bw), 90% (2000 mg/kg bw) and 100% (2500 ml/kg bw) respectively. - Other findings:
- necropsy on animals which died during post-observation period: lung spotted, partly slight emphysema, stomach empty, mucosa of forestomach wihite, hardened, intestine with dark, mucous content.
necropsy of animals killed of post-observation period: mucosa of the forestomach showed a slight hardness, other organs without findings
Any other information on results incl. tables
Signs of intoxication: Central nervous effects with laboured breathing, uncoordinated motions, cyanosis, decreased motility and in higher doses aggresivity and partly cramps.
Biginning of symptoms: 15 to 30 minutes in the lower dose groups and 5 to 10 minutes in the letal dose range.
Duration of symptoms: 2 to 6 days
A dose of 100 mg/kg bw was tolerated by male and female rats without symptoms.
The acute oral LD50 for male rats was 2170 mg/kg bw for male rats and 1525 mg/kg bw for female rats
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Based on EU GHS criteria
- Conclusions:
- Signs of intoxication were apathy. decreased motolity, cyanosis, laboured breathing and cramps. The LD50 for female rats was 1525 mg/kg bw and the LD50 for male rats was 2170 mg/kg bw.
- Executive summary:
Seven or eight groups of 10 male and 10 female young adult Wister rats (weight 160 - 200 g) each reveived per gavage a single dose of 100, 1000, 1500, 1750, 2000, 2500, 3000, or 5000 mg/kg bw (male rats) and 100, 500, 1000, 1250, 1500, 2000, or 2500 mg/kg bw (female rats) 4-trifluormethoxyphenyl isocyanate. The animals were observed for mortality and clinical signs through day 14. A gross pathological examination was performed on animals which died during the observation period or were killed after termination of the study.
Signs of intoxication were apathy. decreased motolity, cyanosis, laboured breathing and cramps. The LD50 for female rats was 1525 mg/kg bw and the LD50 for male rats was 2170 mg/kg bw.
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