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EC number: 203-118-2 | CAS number: 103-50-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978-02 to 1978-03
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Equivalent to OECD 401. No clear deviations observed and sufficiently described. Not GLP. Lack of individual results for gross pathology.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- not specified
- Remarks:
- likely not due to testing date
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Dibenzyl ether
- EC Number:
- 203-118-2
- EC Name:
- Dibenzyl ether
- Cas Number:
- 103-50-4
- Molecular formula:
- C14H14O
- IUPAC Name:
- [(benzyloxy)methyl]benzene
- Details on test material:
- - Name of test material (as cited in study report): oxyde de dibenzyle, benzyl ether
- Physical state: liquid
No further data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CFY
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 84 - 119 g
- Fasting period before study: 12 hr prior (overnight)
No further data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 1.6 to 6.4 mL/Kg bw
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: range finding study LD 50 determined to be between 2.5 and 6.4 mL/Kg bw
No further data - Doses:
- 0.64, 1.6, 2.5, 4 and 6.4 mL /Kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: once a week
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, diuresis
No further data - Statistics:
- LD50 was established based on the method of Weil C.S.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 3.7 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 3.1 - <= 4.6
- Remarks on result:
- other: The density of dibenzylether is 1.0428 g/cm³ at 20°C. Therefore 3.7 ml/kg bw corresponds with 3.86 g/kg bw.
- Mortality:
- Death occured from withing twenty-two hours and forty-six hours of treatment.
- Clinical signs:
- other: Signs of reaction to treatment observed shortly after dosing included pilo-erection, abnormal body carriage(hunched posture) and abnormal gait (waddling). Pilo-erection was also observed in controls animals. Lowest dosed rats exhibited lethargy, increased
- Gross pathology:
- Autopsy revealed congestion and hemorrhage of the lungs, pallor of the liver, kidneys and spleen. Opacity of the eyes was observed.Terminal autopsies of sacrified animals returned normal.
Any other information on results incl. tables
Table 1: Number of animals dead and time range within which mortality occurred
Dose |
Mortality (# dead/total) |
Time range of deaths (hours) |
|||||
Male |
Female |
Combined |
|||||
Control |
0/5 |
0/5 |
- |
- |
|||
1.6 |
0/5 |
0/5 |
- |
- |
|||
2.5 |
1/5 |
1/5 |
- |
< 46 |
|||
4 |
1/5 |
4/5 |
- |
< 22 |
|||
6.4 |
5/5 |
5/5 |
- |
< 22 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In the test conditons the authors established the LD 50 for rats of dibenzyl oxide to 3.7 mL/Kg bw. In the test conditions, dibenzyl oxide should not be classified for acute oral toxicity.
- Executive summary:
In this study, the authors tested the acute oral toxicity of dibenzyl oxide (CAS n° 103-50-4) on CFY rats in a methodology very similar to the OECD guideline 401. The authors monitored for two weeks after a single oral intubation of dibenzyl oxide alone, the behaviour, clinical signs, mortality and body weight gain of male and female treated. Each concentration tested (ranging from 1.6 to 6.4 mL/kg bw) was on five individuals of each sex.
In the test conditions, death occured from within twenty-two hours and fourty-six hours of treatment in both sexes. Signs of reaction to treatment observed shortly after dosing included pilo-erection, abnormal body carriage(hunched posture) and abnormal gait (waddling). Pilo-erection was also observed in controls animals. Lowest dosed rats exhibited lethargy, increased salivation and decreased respiratory rates increasing with test materials concentrations. Diuresis and diarrhoea was observed in high dosed rats. Ataxia, loss of righting reflex, fine body tremors and ptosis were observed amongst treated rats. Three rats appareared in a comatose like condition.
Bodyweight of rats treated at 4 mL/kg bw exhibited signs of depressed body weight gains during firts week but returned normal afterwards. All other surviving treated rats gained bodyweight similarly to controls rats.
Autopsy revealed congestion and hemorrhage of the lungs, pallor of the liver, kidneys and spleen. Opacity of the eyes was observed.Terminal autopsies of sacrified animals returned normal.
In the test conditons the authors established the LD 50 for rats of dibenzyl oxide to 3.7 mL/Kg bw (3.1-4.6). Thus, in the test conditions, dibenzyl oxide should not be classified for acute oral toxicity.
The study is well documented and very similar to a guideline. No obvious deviations to this guideline are observed. Thus this study is considered as relliable with restrictions, a Klimisch 2.b study.
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