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EC number: 287-634-3 | CAS number: 85566-24-1
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility (< 0.02 mg/L at 20 °C, pH 6.3).
Key value for chemical safety assessment
Additional information
Since no studies investigating the toxicity of Fatty acids, C14-18, C14-18-alkyl esters (CAS 85566-24-1) to aquatic algae are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substances Fatty acids, C16-18, C12-18-alkyl esters (CAS 95912-87-1) and Tetradecanoic acid, tetradecyl ester (CAS 3234-85-3) was conducted. The source substances are representative to evaluate the toxicity of the target substance to aquatic algae. The target substance is characterized as an ester of mainly C14 fatty acid/C14 alcohol, C16 fatty acid/C14 alcohol and C16 fatty acid/C16 alcohol. The two source substances are structurally very similar to the target substance. Tetradecanoic acid, tetradecyl ester (CAS 3234-85-3) is a mono-constituent substance of a C14 fatty acid esterified with C14 alcohol. Fatty acids, C8-10, C12-18-alkyl esters (CAS 95912-86-0) is a UVCB substance consisting of mainly C8-C10 fatty acids esterified with C12-C14 alcohol. This read-across is justified in detail in the overall summary (IUCLID Section 6.1) and within the analogue justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment.
The study with the read-across substance tetradecyl myristate (CAS 3234-85-3) was performed according to OECD 201 (GLP) and investigated the toxicity to freshwater algae (Wenzel, 2012). The green algae Pseudokirchneriella subcapitata was exposed for 72 h to a limit Water Accommodated Fraction (WAF) concentration of nominal 100 mg/L. GC/EI-MS analysis resulted in a measured concentration of 0.142 µg/L (arithmetic mean) over the time of exposure. No effects on growth and yield of algae were observed resulting in an EL50 of > 100 mg/L (nominal) and > 1.465 µg/L (arithmetic mean of measured concentration), respectively. The NOELR was derived to be ≥ 100 mg/L (nominal) and ≥ 1.465 µg/L (arithmetic mean of measured concentrations).
The second study with Fatty acids, C8 - 10, C12 - 18-alkyl esters (CAS 95912-86-0) was performed according to OECD 201 (GLP) is available investigating the toxicity to aquatic algae (Salinas, 2013). Desmodesmus subspicatus was exposed to nominal loading rates of 10, 32, 100, 320 and 1000 mg/L for 72 h (Water Accommodated Fraction). No effects were observed on growth and yield after 72 h of incubation resulting in an EL50 (72 h) > 1000 mg/L (nominal) and a NOELR (72 h) ≥ 1000 mg/L (nominal).
Based on the available results from structurally related read-across substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which are characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that Fatty acids, C14-18, C14-18-alkyl esters will not exhibit effects on aquatic algae up to the limit of water solubility.
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