Registration Dossier
Registration Dossier
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EC number: 287-634-3 | CAS number: 85566-24-1
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility (< 0.02 mg/L at 20 °C, pH 6.3).
Key value for chemical safety assessment
Additional information
Since no studies investigating the short-term toxicity of Fatty acids, C14-18, C14-18-alkyl esters (CAS 85566-24-1) to aquatic invertebrates are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substances Fatty acids, C16-18, C12-18-alkyl esters (CAS 95912-87-1) and Tetradecanoic acid, tetradecyl ester (CAS 3234-85-3) was conducted. The source substances are representative to evaluate the short-term toxicity of the target substance to aquatic invertebrates. The target substance is characterized as an ester of mainly C14 fatty acid/C14 alcohol, C16 fatty acid/C14 alcohol and C16 fatty acid/C16 alcohol. The source substances are structurally very similar to the target substance. Fatty acids, C16-18, C12-18-alkyl esters (CAS 95912-87-1) is a UVCB substance consisting of C16-C18 fatty acids esterified with C12-C18 alcohol. Tetradecanoic acid, tetradecyl ester (CAS 3234-85-3) is a mono-constituent substance of a C14 fatty acid esterified with C14 alcohol. This read-across is justified in detail in the overall summary (IUCLID Section 6.1) and within the analogue justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment.
The first study with the read-across substance Fatty acids, C16-18, C12-18-alkyl esters (CAS 95912-87-1) was performed according to EU Method C.2 (GLP) under static conditions with the water flea Daphnia magna (Wierich, 2001). A Water Accommodated Fraction of nominal 100 mg/L was tested in this study. Measured concentrations were in the range of 0.1 - 0.2 mg/L or even below the detection limit (GC analysis). After 48 h no effects on the test organisms were observed resulting in an EL50 > 100 mg/L.
The second study with the read-across substance tetradecyl myristate (CAS 3234-85-3) was conducted according to OECD 202 (GLP) and investigated the short-term effects to freshwater invertebrates (Schlechtriem, 2012). Daphnia magna was exposed to a Water Accommodated Fraction (WAF) of nominal 100 mg/L in a limit test for 48 h. GC/EI-MS analysis resulted in a measured geometric mean concentration of 0.128 µg/L. No immobilization was recorded after 48 h resulting in an EL50 of > 0.128 µg/L (measured, geometric mean) and > 100 mg/L (nominal), respectively.
Based on the available results from structurally related read-across substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which are characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that Fatty acids, C14-18, C14-18-alkyl esters will not exhibit short-term effects to aquatic invertebrates up to the limit of water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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