Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 815-500-1 | CAS number: 1853175-99-1
Endpoint summary
Administrative data
Description of key information
Three acute experimental studies and two QSAR predictions are available to assess the aquatic toxicity of the registered substance.
For algae, the experimental study performed on Desmodesmus subspicatus, was not considered reliable due to insufficient information provided on the methodology used. Therefore, QSAR prediction for this endpoint was performed using iSafeRat® High-Accuracy-Quantitative Structure-Activity Relationship (KREATIS, 2019). Toxic effect was predicted in acute conditions, with a 72h-ErC50 value calculated at 1.2 mg/L.
For aquatic invertebrates, the experimental study performed on Daphnia magna was considered reliable with restrictions due to the use of acetone as solvent in quantity 20 times higher than the acceptable quantity (2 mL/L instead of max. 0.1 mL/L) but 5 times lower than the EC50 of acetone. In this study, the 48h-EC50 value was determined at 2.2 mg/L based on analytically confirmed nominal concentrations. This result supports the more conservative QSAR prediction using iSafeRat® High-Accuracy-Quantitative Structure-Activity Relationship (KREATIS, 2019). Toxic effect was predicted in acute conditions, with a 48h-ErC50 value calculated at 1.5 mg/L. Due to the vulnerability of the experimental study, the QSAR prediction was considered as the key data.
For fish, the experimental study performed on Danio rerio was considered reliable with restrictions due to the use of acetone as solvent but in acceptable quantity (0.125 mL/L). The 96h-LC50 value was determined to be greater than the maximum tested concentration, measured at 5.4 mg/L (geometric mean measured concentrations).
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
