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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
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Diss Factsheets
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EC number: 815-500-1 | CAS number: 1853175-99-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Hazard for air
Hazard for terrestrial organisms
Hazard for predators
Additional information
Aquatic toxicity:
Three acute experimental studies and two QSAR predictions are available to assess the aquatic toxicity of the registered substance.
For algae, the experimental study performed on Desmodesmus subspicatus was not considered reliable due to insufficient information provided on the methodology used. Therefore, QSAR prediction for this endpoint was performed using iSafeRat® High-Accuracy-Quantitative Structure-Activity Relationship (KREATIS, 2019). Toxic effect was predicted in acute conditions, with a 72h-ErC50 value calculated at 1.2 mg/L.
For aquatic invertebrates, the experimental study performed on Daphnia magna was considered reliable with restrictions due to the use of acetone as solvent in quantity 20 times higher than the acceptable quantity (2 mL/L instead of max. 0.1 mL/L) but 5 times lower than the EC50 of acetone. In this study, the 48h-EC50 value was determined at 2.2 mg/L based on analytically confirmed nominal concentrations. This result supports the more conservative QSAR prediction using iSafeRat® High-Accuracy-Quantitative Structure-Activity Relationship (KREATIS, 2019). Toxic effect was predicted in acute conditions, with a 48h-ErC50 value calculated at 1.5 mg/L. Due to the vulnerability of the experimental study, the QSAR prediction was considered as the key data.
For fish, the experimental study performed on Danio rerio was considered reliable with restrictions due to the use of acetone as solvent but in acceptable quantity (0.125 mL/L). The 96h-LC50 value was determined to be greater than the maximum tested concentration, measured at 5.4 mg/L (geometric mean measured concentrations).
Environmental fate and pathways:
Based on the key biodegradation study (OECD Guideline 301D, GLP), the registered substance is not readily biodegradable but ultimately (completely) biodegradable (45% biodegradation after 28 days and 72% biodegradation after 60 days). Therefore, the registered substance is not persistent in the environment. In addition, with a log Kow value determined experimentally at 4.37, the substance is considered to be bioaccumulative according to CLP (>4.0) but not bioaccumulative according to PBT criteria (<4.5).
Conclusion on classification
No harmonised classification is available.
Data available:
- Lowest E(L)C50 value comprised between 1 and 10 mg/L (M-factor not applicable);
- Not rapidly degradable;
- log Kow > 4.
Classification according to the Annex VI of the Regulation (EC) No 1272/2008 (CLP): The registered substance is classified as Aquatic Chronic 2 for the environment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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