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EC number: 203-402-6 | CAS number: 106-48-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April to June 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not specified
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.2 (Acute Toxicity (Inhalation))
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- traditional method
- Limit test:
- yes
Test material
- Reference substance name:
- 4-chlorophenol
- EC Number:
- 203-402-6
- EC Name:
- 4-chlorophenol
- Cas Number:
- 106-48-9
- Molecular formula:
- C6H5ClO
- IUPAC Name:
- 4-chlorophenol
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- TNO/W 74
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Recognised supplier
- Age at study initiation: not specified
- Weight at study initiation: 150-200g
- Fasting period before study: 16h
- Housing: Makrolon cages (type III/II)
- Diet (e.g. ad libitum): Altromin-R rat and mouse maintenance diet, provided ad libitum (except for exposure period)
- Water (e.g. ad libitum): water, ad libitum (except for exposure period)
- Acclimation period: not specified; study reports state that animals were "soberly handled" (implies handled carefully/gently)
ENVIRONMENTAL CONDITIONS
- Temperature (°C): not specified
- Humidity (%): not specified
- Air changes (per hr): not specified
- Photoperiod (hrs dark / hrs light): not specified
IN-LIFE DATES: April - June 1980.
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: vapour-enriched clean air
- Remark on MMAD/GSD:
- No specific mention of MMAD/GSD in study report; 200 L/h air was supplied with 150 g heated (melted), dynamically-evaporated test-item.
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: The test item was heated to 55-57 °C, in order to melt it. The melted test item was then "dynamically evaporated" into a 200 L/hour flow of moisture-enriched, clean air.
- Exposure chamber volume: 10 L PVC box for whole-body exposure.
- Method of holding animals in test chamber: Not applicable; animals were in chamber for whole-body exposure.
- Source and rate of air: Unspecified source; 200L/h flow-rate.
- Method of conditioning air: moisture-enrichment.
- System of generating particulates/aerosols: Not specified; some sort of atomiser/nebuliser is implied by the test ("dynamic evaporation").
- Method of particle size determination: Not reported.
- Treatment of exhaust air: Not reported.
- Temperature, humidity, in air chamber: Not reported.
TEST ATMOSPHERE
- Brief description of analytical method used: Not reported; total exposure is calculated or inferred from the quantity of test item vapourised into the air stream entering the test chamber.
- Samples taken from breathing zone: Not reported.
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: Not reported.
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): Not reported. - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 7 h
- Concentrations:
- 200 L/h air was supplied with ~150g test item, indicating a concentration of ~0.11 g/L test item.
- No. of animals per sex per dose:
- 5 per sex per dose.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Mortality, daily. Clinical signs during exposure and over the course of day one, followed by daily. Any evidence of mortality or overt toxicity was recorded at each observation. Individual body weights were recorded prior to treatment on the day of exposure and once weekly thereafter.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, and any other relevant toxicological effects were reported. - Statistics:
- Where necessary, lethal dose calculations (mean) and confidence intervals were calculated with "Probit-Analyse" (Fink & Hund, Arzneimittelforschung 15, 624, 1965).
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LCLo
- Effect level:
- > 110 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 7 h
- Remarks on result:
- not determinable
- Remarks:
- All animals survived for 14 days after a 7h exposure to approximately 0.11g/L (110mg/L) of the test item.
- Mortality:
- No mortalities occurred during the study period.
- Clinical signs:
- other: During exposure, excited states were observed for all animals, accompanied by slight irritation of the nasal mucous membranes. No other clinical signs were seen for the animals.
- Body weight:
- All animals showed expected gains in bodyweight.
- Gross pathology:
- At autopsy, 2/5 male and 1/5 female rats had "lung-changes" (dark red or grey discolouration with "bloomed" areas). The other rats "appeared normal".
- Other findings:
- - Organ weights: Not reported.
- Histopathology: Not reported.
- Potential target organs: Not applicable.
- Other observations: Not applicable.
Any other information on results incl. tables
Additional comments regarding test atmosphere generation:
Due to the solid state of the test item at standard temperature and pressure, the test item had a tendency to condense on the walls of the delivery tubing and test chamber. Solidified test-item had to be periodically re-evaporated by pouring warm water over the affected areas of tubing or test-chamber wall.
Table 1. Mortality data summary:
Group Number |
Estimated Atmosphere Concentration (mg/L) |
Mortalities |
||
|
|
Female |
Male |
Total |
1 |
110 |
0/5 |
0/5 |
0/10 |
|
|
|
|
|
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the study, the inhalation 7h-LC50 (male/female) was considered to be >110 mg/L within the TNO/W 74 Wistar rat.
- Executive summary:
The study was performed historically according to a method similar to OECD TG 403 and EU Method B.2, to assess the acute inhalation toxicity of the test item. A single group of ten Wistar: TNO/W 74 strain rats (five males and five females) were exposed to an aerosol atmosphere of the test item. The groups were exposed for seven hours using a full-body exposure system, followed by a fourteen day observation period. The estimated mean atmosphere concentration was 110 mg/L. Mean Mass Median Diameter (particle size) and geometric Standard Deviation were not reported. There were no mortalities in the estimated 110 mg/L achieved atmosphere concentration. Some nasal mucous membrane irritation and "excited states" in the rats were observed. After exposure, no clinical signs were observed for any animals, and the study authors remark that following exposure they all appeared to "meet the physiological norm" and show expected gains in bodyweight. 2/5 male and 1/5 female rats showed lung abnormalities at macroscopic post-mortem examination (dark red or grey discolouration with "bloomed" areas). No abnormalities were found at macroscopic post-mortem examination in the other rats. Under the conditions of this study, the inhalation 7h-LC50 (male/female) could not be determined, and was therefore considered to be >110 mg/L within the Wistar: TNO/W 74 rat.
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