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EC number: 279-075-9 | CAS number: 79135-28-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Aquatic invertebrates: EC50 (48h) = 63.7 mg/l
Aquatic plants: ErC50 (7d) = 119.829 mg/l based on frond number
Additional information
The assessment on aquatic toxicity was based on data on Acid Brown 303 and on a structural analogue, i.e. Similar Substance 01.
Details on the read-across are available in section 13.
Short-term toxicity to fish
An
old study on Acid Brown 303 reported an LC50 (48h) above 1400 ppm
wt/vol. Due to the lack of details, the reliability of such study could
not be ascertained, thus it was not used for classification purposes.
Short-term toxicity to aquatic invertebrates
Similar Substance 01 was tested for acute toxicity to Daphnia magna, according to OECD guideline 202.
The EC50 value at 48 hours was 63.7 mg/l.
Toxicity to aquatic plants
Acid Brown 303 was tested for Lemna sp. according to OECD guideline 221 over a period of 7 days (168 hours) under static conditions.
The ErC50 value for growth rate based on frond number was found to be 119.829 mg/l.
Toxicity to microorganisms
Acid Brown 303 was tested according to OECD guideline 303 and caused no inhibition of the respiration rate at the highest tested concentration. Accordingly, IC50 (3h) was greater than 100 mg/l.
Justification for classification
Within the CLP Regulation (EC 1272/2008), classification for acute and chronic aquatic toxicity is based on data on fish, crustacea and algae or other aquatic plants. In particular, classification for acute toxicity applies when LC50 (96h) on fish, and/or, EC50 (48h) on crustacea and/or ErC50 (72 or 96h) on algae is ≤ 1 mg/l.
In case of lack of adequate chronic toxicity data, classification for chronic toxicity is based on acute toxicity data. In particular, classification in:
- category chronic 1 applies for acute toxicity data ≤ 1 mg/l;
- category chronic 2 applies for acute toxicity data between 1 and 10 mg/l;
- category chronic 3 applies for acute toxicity data between 10 and 100 mg/l.
Based on the available data on crustacea and aquatic plants, the substance is classified as category chronic 3 (H412), according to the CLP Regulation n. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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