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Diss Factsheets
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EC number: 605-140-1 | CAS number: 158237-07-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
The criteria given in the “Guidance on information requirements and chemical safety assessment, chapter R.11: PBT Assessment” (ECHA, 2017) are used to decide if the substance fulfils the PBT/vPvB-criteria.
Persistence Assessment
In a screening study (1999) with activated sludge 0% biodegradation was observed. Thus, the test substance is not readily biodegradable according to the OECD criteria. Further simulation studies with paddy soils investigated the biodegradation potential of the substance (1995, 1997b). Under the laboratory conditions chosen (experiments were conducted at 28 °C) these studies resulted in a maximum half-life of 46 days. However, according to the ECHA guidance "Guidance on Information Requirements and Chemical Safety Assessment. Chapter R.7b: Endpoint specific guidance. Version 4.0" (2017) the preferred temperature for simulation degradation studies is 12 °C, which corresponds to average temperature of European surface waters. Where this condition is not met a temperature correction should be considered based on the Arrhenius equation and half-lives be re-calculated. For first order kinetics this was done and the half-life of 46 days (at 28 °C) was re-calculated to 199 days (at 12 °C), respectively. Data from a short communication (2001) referring to a field test indicate shorter half-lives. However, the information provided is insufficient for assessment. Thus, based on a worst case assumption and all available data the substance has to be regarded as being very persistent.
Bioaccumulation Assessment
The potential for bioaccumulation was investigated in a study using radiolabeled test substance (2007).The substance accumulated in bluegill sunfish with a total residue kinetic bioconcentration factor of about 275.5 to 289.8 X for whole fish (sum of radio labelled compounds, parent substances, metabolites and mineralization products). When exposure ceases, the residues were depurated with a half-life of about 0.42 to 0.55 days. After 14 days in uncontaminated water 100 % of the mean plateau radioactivities were depurated from whole fish in both test levels. Accumulations of total residues in edible parts were less (116.9 – 153.6 X) than in whole fish (275.5 – 289.8 X). Taking into account that about 30 % parent compound were detected in edible parts and about 16% parent compound in non-edible (viscera) parts after 15 days of exposure the steady-state-BCF for parent (based on whole fish, wet weight) is about 71, the steady-state-BCF for parent (normalised to 6% lipid content) is about 54.
Thus, the substance has a low potential to bioaccumulate in aquatic organisms.
Toxicity Assessment
Based on the available data the substance is considered to be toxic. The substance is classified as H373 according to Regulation (EC) No 1272/2008 and thus meets the T-criterion.
In conclusion, the substance is not PBT/vPvB.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.