Registration Dossier
Registration Dossier
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EC number: 206-312-5 | CAS number: 326-61-4
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- Piperonyl acetate
- EC Number:
- 206-312-5
- EC Name:
- Piperonyl acetate
- Cas Number:
- 326-61-4
- Molecular formula:
- C10H10O4
- IUPAC Name:
- (2H-1,3-benzodioxol-5-yl)methyl acetate
- Reference substance name:
- Piperonyl alcohol
- EC Number:
- 207-808-4
- EC Name:
- Piperonyl alcohol
- Cas Number:
- 495-76-1
- Molecular formula:
- C8H8O3
- IUPAC Name:
- 1,3-benzodioxol-5-ylmethanol
Constituent 1
impurity 1
- Specific details on test material used for the study:
- Batch no.: 18040126
Appearance: colourless liquid
Purity: 99.80% (GC)
Homogeneity: homogeneous
Expiry date: 23. May 2020
Storage: room temperature (20 ± 5°C)
Density: 1.237 g/cm3
Storage: the test item was stored in a closed vessel at room temperature (20 ± 5°C), dry, in the dark.
Results and discussion
Water solubility
- Key result
- Water solubility:
- ca. 1.19 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- >= 4.21 - <= 4.28
Any other information on results incl. tables
* Deviations from the Study Plan
The following deviations from the study plan were documented; in the preliminary test the nominal load 200 g/L was tested instead of 20 g/L. This was considered as uncritical as an excess of the test item was necessary in the preliminary test and a higher excess was used. The deviation was assessed and signed by the study director on 02. Apr. 2019.
The calibration was not renewed although the recovery rate of QC sample was higher than 115 %. This was considered as uncritical as a fresh prepared QC sample was measured and the recovery rate lay in the range of 100±15 %. The deviation was assessed and signed by the study director on 09. Apr. 2019.
Applicant's summary and conclusion
- Conclusions:
- According to OECD 105, the water solubility of the test item is:
1.19 ± 0.08 g/L at 20.0 ± 0.5 °C and pH 4.21 – 4.28
= 1.19 ± 0.08 kg/m3(SI units)
(mean value ± standard deviation)
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