Registration Dossier
Registration Dossier
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EC number: 942-582-7 | CAS number: -
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- See attached document below.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 3 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 790 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Conclusions:
- Based on a worse case approach taking into account the highest toxicity observed to activated sludge with the 2 source substances [Sodium sulfate (CAS 7757-82-6) and calcium sulfate (CAS 7778-18-9)], the 3h-NOEC value of 790 mg/L was attributed to the target substance "Sulphates of potassium, sodium and calcium, by-product from fermentation”. Even if a microorganism toxicity test is not available for potassium sulphate, an adverse effect is not suspected for this source substance, due to the very high EC50/NOEC obtained with the 2 other salts (same category in OECD program) and the total absence of adverse effects observed with these 3 salts to all tested aquatic organisms.
- Executive summary:
The results of the toxicity to microorganisms are indicative of a similar vey low toxicity of sodium sulfate (CAS 7757-82-6) and calcium sulfate (CAS 7778-18-9), with a 37d-NOEC = 8000 mg/L and a 3h-NOEC = 790 mg/l respectively.
Based on a worse case approach taking into account the highest toxicity observed to activated sludge with the 2 source substances, Sodium sulfate and Calcium sulfate, the 3h-NOEC value of 790 mg/L was attributed to the target substance "Sulfates of potassium, sodium and calcium, by-product from fermentation”. Even if a microorganism toxicity test is not available for potassium sulphate, an adverse effect is not suspected for this source substance, due to the very high NOEC obtained with the 2 other salts (same category than potassium sulfate in the OECD program) and the total absence of adverse effects observed with these 3 salts to all tested aquatic organisms.
Reference
Description of key information
Based on a worse case approach taking into account the highest toxicity observed to activated sludge with the 2 source substances [Sodium sulfate (CAS 7757-82-6) and calcium sulfate (CAS 7778-18-9)], the 3h-NOEC value of 790 mg/L was attributed to the target substance "Sulfates of potassium, sodium and calcium, by-product from fermentation”. Even if a microorganism toxicity test is not available for potassium sulphate, an adverse effect is not suspected for this source substance, due to the very high EC50/NOEC obtained with the 2 other salts (same category in the OECD program) and the total absence of adverse effects observed with these 3 salts to all tested aquatic organisms.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 790 mg/L
Additional information
The results of the toxicity to microorganisms are indicative of a similar vey low toxicity of sodium sulfate (CAS 7757-82-6) and calcium sulfate (CAS 7778-18-9), with a 37d-NOEC = 8000 mg/L and a 3h-NOEC = 790 mg/l respectively.
Based on a worse case approach taking into account the highest toxicity observed to activated sludge with the 2 source substances, Sodium sulfate and Calcium sulfate, the 3h-NOEC value of 790 mg/L was attributed to the target substance "Sulfates of potassium, sodium and calcium, by-product from fermentation”. Even if a microorganism toxicity test is not available for potassium sulphate, an adverse effect is not suspected for this source substance, due to the very high NOEC obtained with the 2 other salts (same category than potassium sulfate in the OECD program) and the total absence of adverse effects observed with these 3 salts to all tested aquatic organisms.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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