Sodium undec-10-enoate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

21/03/2002

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2002

Report date:

2012

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

yes

Test type:

acute toxic class method

Test material

Test material information

Constituent 1

Reference substance name:

Sodium undec-10-enoate

EC Number:

222-264-8

EC Name:

Sodium undec-10-enoate

Cas Number:

3398-33-2

Molecular formula:

C11H20O2.Na

IUPAC Name:

sodium undec-10-enoate

Specific details on test material used for the study:

sodium undec-10-enoate in a 33.2% aqueous solution administered at 2000mg/kg corresponds to 664 mg/kg of pure sodium undec-10-enoate.

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

5 males and 5 females

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

The test substance was administered to a group of 10 fasted Sprague-Dawley rats (5 males and 5 females). The administration was performed with the test substance in its original form (sodium undec-10-enoate in a 33.2% aqueous solution) at a dose level of 2000 mg/kg (corresponds to 664 mg/kg of pure sodium undec-10-enoate) taking into consideration that the specific gravity of the test substance was 1.032.

Doses:

2000 mg/kg

No. of animals per sex per dose:

5 males and 5 females

Control animals:

no

Details on study design:

the mortality, general behaviour and bodyweight gain of the animals were observed for a period of 14 days after the sigle administration of the test substance . A necropsy was performed on each animal sacrificed at the end of the study.

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

>= 664 mg/kg bw

Based on:

test mat.

Mortality:

no mortality at the dose level of 664 mg/kg of sodium undec-10-enoate.

Clinical signs:

other: the general behaviour of the animals was not influenced by the treatment.

Gross pathology:

The macroscopic examination revealed no abnormality in the animals sacrificed at the end of the study.

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

sodium undec-10-enoate (in a 33.2% aqueous solution) administered by oral route in the Rat was higher than 2000 mg/kg, i.e. higher than 664 mg/kg of pure sodium undec-10-enoate. No signs of toxicity were observed at this dose level.

Executive summary:

The acute oral toxicity study was performed according to the OECD 401 guideline. The substance sodium undec-10-enoate (in a 33.2% aqueous solution) administered by oral route in the Rat was higher than 2000 mg/kg, i.e. higher than 664 mg/kg of pure sodium undec-10-enoate. No signs of toxicity were observed at this dose level.