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EC number: 483-270-6 | CAS number: 54068-28-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2011
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- -
- EC Number:
- 483-270-6
- EC Name:
- -
- Cas Number:
- 54068-28-9
- Molecular formula:
- Hill formula: C26H48O4Sn CAS formula: C26H48O4Sn
- IUPAC Name:
- (3Z)-4-{[dioctyl({[(2Z)-4-oxopent-2-en-2-yl]oxy})stannyl]oxy}pent-3-en-2-one
- Details on test material:
- TIB KAT 223 Ch. VP10-054
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- other: Nulliparous,e CBA/Ca
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- dimethyl sulphoxide
- Concentration:
- 100, 50, 25, 10, 5, 2.5, 0 percent
- No. of animals per dose:
- 4
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: 100 v/v % : SI=9.8 50 v/v % : SI=3.3 25 v/v % : SI=6.4 10 v/v % : SI=5.1 5 v/v % : SI=1.2 2.5 v/v % : SI=1.4
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: vehicle M1: DPM=419 100 v/v % : DPM=4089 50v/v % : DPM=1381 25v/v % : DPM=2661 vehicle M2: DPM=159 10v/v % : DPM=814 5v/v % : DPM=180 2.5v/v % : DPM=224
Applicant's summary and conclusion
- Interpretation of results:
- other: sensitising in concentration >5 v/v %
- Remarks:
- Criteria used for interpretation of results: OECD GHS
- Conclusions:
- The Local Lymph Node Assay demonstrated that TIB KAT 223 (Tin, dioctylbis(2,4-pentanedionato-κO2,κO4)-) has the potential to cause skin sensitisation at concentrations of 10% v/v and higher. However, at concentrations of 5% and under, TIB KAT 223 (Tin, dioctylbis(2,4-pentanedionato-κO2,κO4)-) does not cause skin sensitisation.
- Executive summary:
This study was conducted to assess the potential of the test article, TIB KAT 223 (Tin, dioctylbis (2,4-pentanedionato-O,O’)-), to cause skin sensitisation in the mouse.
Following a preliminary screening test using the undiluted test article, the test article was prepared for administration at 2.5, 5, 10, 25 and 50% in DMSO together with undiluted test article. Groups of four female CBA / Ca mice were subjected to topical applications of vehicle or of one of the test formulations to the outer aspect of the auditory pinnae once daily on Days 1, 2 and 3. On Day 6 a 20 μCi dose of tritiated3H-methyl thymidine was injected intravenously into each mouse. Five hours later the auricular lymph nodes were recovered from each animal. The nodes from mice subjected to the same treatment were pooled and suspensions of the cellular components of the lymph nodes were prepared in 5% w/v trichloroacetic acid and processed through a scintillation counter.
Test results are expressed in terms of Stimulation Indices, the ratios of the mean scintillation count per group obtained from the test groups relative to the corresponding mean scintillation count from controls. The threshold level for the Stimulation Index to be considered a positive indicator of the potential to cause skin sensitisation is 3.0.
Concentration of test article in applied formulation(% v/v)
25%
50%
100%
Stimulation Index
6.4
3.3
9.8
The stimulation indices were above the threshold level of 3.0, therefore an additional phase was performed at the request of the Sponsor. In the additional phase, the test article was prepared for administration at 2.5, 5 and 10% in DMSO.
Concentration of test article in applied formulation(% v/v)
2.5%
5%
10%
Stimulation Index
1.4
1.2
5.1
The EC3 value for TIB KAT 223 (Tin, dioctylbis (2,4-pentanedionato-O,O’)-) was 7.3.
The Local Lymph Node Assay demonstrated that TIB KAT 223 (Tin, dioctylbis (2,4-pentanedionato-O,O’)-) has the potential to cause skin sensitisation.
The EC3 value estimates that at concentrations above 7.3% v/v the test article would elicit skin sensitisation.
The test article was classified as a Category 1 sensitiser according to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS).
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