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EC number: 483-270-6 | CAS number: 54068-28-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD nø 423 (24 April 2002) Test method B.1tris directive 2004/73/EC
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Groupe Interminsteriel Des Produits Chimiques, Paris, France
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 483-270-6
- EC Name:
- -
- Cas Number:
- 54068-28-9
- Molecular formula:
- Hill formula: C26H48O4Sn CAS formula: C26H48O4Sn
- IUPAC Name:
- (3Z)-4-{[dioctyl({[(2Z)-4-oxopent-2-en-2-yl]oxy})stannyl]oxy}pent-3-en-2-one
- Details on test material:
- VP07-560
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: no vehicle
- Doses:
- Control: 2 ml/kg bw distilled water
Treated: 1,79 ml/kg bw TIB KAT 223 ( = 2000 mg/kg bw) - No. of animals per sex per dose:
- Control: 6
Treated: 6 - Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 500 mg/kg bw
- Mortality:
- Female: CA 2000 mg/kg bw; Number of animals: 3; Number of deaths: 1
Female: CA 2000 mg/kg bw; Number of animals: 3; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: It was registered in the treated animals, from 30 minutes after the test item administration, a decrease of the spontaneous activity (6/6) associated with an absence of Preyer's reflex (5/6), a bradypnea (6/
- Gross pathology:
- Effects on organs:
The macroscopical examination of the animal which died
during the study revealed the presence of
black spots at the level of the corpus.
The macroscopical examination of the animals at the end of
the study did not reveal treatment-related
changes.
Any other information on results incl. tables
It was noted the dead of one of treated rat, 48 hours after the test item adnministration.
It was registered in the treated aninmals, from 30 miniutes after the test item administration, a decrease of spontanous acitvity (6/6) assoziated with an absence of Preyer´s reflex (5/6), a bradypneu (6/6), a decrease of muscle tone (5/6), the eyes partly closed (5/6), an increase of lachrymation (3/6), a decrease or an absence of righting reflex (5/6), tremors (2/6) an a piloerection (6/6). The animals recovered a normal activity between the 2nd day and the 3rd day of the test.
A deacrease of the body weight gain was noted in all treated animals, 48 hours after the test item administration. Then the body weight evolution of the animals remsined normal similar between treated and the controll animals.
The macroscopical examination of the animal which died during the study revealed the presend of black spots at the level of the corpus.
The macroscopical examination of the animals of the end of the study did not reveal tredment-related changes.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In conclusion, the LD_{50} of the test item TIB KAT 223 is 2500 mg/kg bw in the oral route in the rat.
-> EEC/67/548: no classification, no symbol and risk phrase
-> 1272/2008/EC: must not be classified in Cat.4, no signal word and hazard statement are required.
Remark: Classification in the UN GHS System is Cat.5
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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