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EC number: 611-821-4 | CAS number: 5934-29-2
Vapour pressure
Administrative data
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Nov 2017 - Apr 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7950 (Vapor Pressure)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- effusion method: isothermal thermogravimetry
Test material
- Reference substance name:
- L-Histidine Hydrochloride Monohydrate
- EC Number:
- 611-821-4
- Cas Number:
- 5934-29-2
- Molecular formula:
- C6-H9-N3-O2.Cl-H.H2-O
- IUPAC Name:
- L-Histidine Hydrochloride Monohydrate
- Test material form:
- solid: crystalline
- Details on test material:
- - Name: L-Histidine Hydrochloride Monohydrate (HHM)
- Appearance: White crystals or crystalline powder
- Batch: P817T011
- CAS no.: 5934-29-2
- Purity/Composition: 100.1%
- Molecular weight: 209.63 g/mol
- Test item storage: room temperature
- Expiry date: 31 October 2020
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Batch No.of test material: P817T011
- Expiration date of the lot/batch: 31 October 2020
- Purity: 100.1%
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature
Results and discussion
Vapour pressureopen allclose all
- Key result
- Temp.:
- 20 °C
- Vapour pressure:
- < 0.002 Pa
- Key result
- Temp.:
- 20 °C
- Vapour pressure:
- < 0 mm Hg
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- < 0.004 Pa
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- < 0 mm Hg
Applicant's summary and conclusion
- Conclusions:
- Vapour Pressure of the Test Item at 20°C = < 1.5 x 10^-3 [Pa], < 1.1 x 10^-5 [mm Hg]
Vapour Pressure of the Test Item at 25°C = < 4.0 x 10^-3 [Pa], < 3.0 x 10^-5 [mm Hg] - Executive summary:
The isothermal thermogravimetric effusion method.was applied for the determination of the vapour pressure of L-Histidine Hydrochloride Monohydrate (HHM). The study was conducted accoring to EC Guideline A.4. Vapour Pressure, OECD Guideline104. Vapour Pressure, and EPA Product Properties Test Guideline OPPTS 830.7950: Vapor pressure. The test item contains crystal water. In the preliminary test there was a weight loss observed from about 160°C. This weight loss was considered deriving from the loss of crystal water. As the crystal water was a part of the chemical structure of L-Histidine Hydrochloride Monohydrate (HHM), its loss was considered degradation of the test item. Weight losses at temperatures > 150°C were, therefore, not included in the determination of the vapour pressure. Another weight loss was observed from approximately 250°C. This was considered due to degradation of the test item, too. A representative weight loss curve of the test item was in the range of 110°C - 130°C. In the range of 110°C, 120°C and 130°C a log p versus 1/T curve for the test item could not be determined since the coefficient of correlation (r) was < 0.99. This is most likely due to the start of reaction and/or decomposition of the test item. Since no accurate vapour pressure could be calculated from the obtained results the weight losses of the test item were compared with the results of hexachlorobenzene at the same temperatures. Since the weight loss of the test item was lower than the weight loss of the reference compound, the vapour pressure of the test item is considered to be below the vapour pressure of hexachlorobenzene.
Vapour Pressure of the Test Item at 20°C = < 1.5 x 10^-3 [Pa], < 1.1 x 10^-5 [mm Hg]
Vapour Pressure of the Test Item at 25°C = < 4.0 x 10^-3 [Pa], < 3.0 x 10^-5 [mm Hg]
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