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EC number: 292-081-6 | CAS number: 90530-40-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Use of dispersant and several test concentrations, including the EC50 above the solubility limit.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- not specified
- Analytical monitoring:
- yes
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- - Test Organisms:
a) Age: < 24 hours old
b) Supplier/Source: Test daphnids were obtained from the National Institute for Environmental Studies (JAPAN) and reproduced by the testing laboratory. - Test type:
- static
- Test temperature:
- 19.9 - 20.1 ºC
- pH:
- 7.6 - 8.0
- Dissolved oxygen:
- 7.8 - 8.6 mg/L
- Nominal and measured concentrations:
- Nominal Concentrations: control , solvent control (HCO-40: 90 mg/L), 1.00, 1.80, 3.10, 5.50, 9.70, 17.0 and 30.0 mg/L
- Details on test conditions:
- - Test Conditions:
a) Dilution Water Source: Dechlorinated tap water
b) Dilution Water Chemistry: pH: = 8.1 (22ºC) Electric conductivity: = 180 uS/cm Total hardness (as CaCO3): = 63 mg/L Alkalinity (as CaCO3): = 45 mg/L
c) Exposure Vessel Type: 100 mL test solution in a 100 mL Glass Beaker with Teflon-lined cap
d) Nominal Concentrations: control , solvent control (HCO-40: 90 mg/L), 1.00, 1.80, 3.10, 5.50, 9.70, 17.0 and 30.0 mg/L
e) Vehicle/Solvent and Concentrations: HCO-40: All test solutions contained 90 mg/L HCO-40.
f) Stock Solutions Preparations and Stability: 1,000 mg/L stock solution was prepared.
g) Number of Replicates: 4
h) Individuals per Replicates: 5
i) Water Temperature: 20±1ºC
j) Light Condition: 16:8 hours, light-darkness cycle (=< 1,200 lux)
k) Feeding: None
- Statistical Method: a) Data Analysis: Probit method for EC50 b) Method of Calculating Mean Measured Concentrations: Geometric Mean - Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 2.48 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 4.56 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95 % C.I.; 3.89 - 5.27 mg/L; Rem: Value above the limit of solubility and therefore of limited reliability
- Conclusions:
- the 48 h EC50 of the test substance to Daphnia magna was 4.56 mg/L.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: EPA guideline similar to OECD-guideline.
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 797.1300 (Aquatic Invertebrate Acute Toxicity Test, Freshwater Daphnids)
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- At each sampling period 5 ml aliquots of test water were collected from each of the four replicates of each test solution. Two replicates at each time
point were composited. - Vehicle:
- no
- Details on test solutions:
- A primary stock standard of MAA was prepared and stored at room temperature. Subsequent dilutions were prepared in Milipore water for use as
spiking solutions and test dilution water. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- ABC Laboratories in house culture. Age at study initiation: first instar (<=24 hours old). Organisms were held in temperature controlled area at 20°C. Lighting was 50-70 footcandles on a 16 hr photoperiod, with 30 minute dawn and dusk transition periods, Oragnisms were not fed during the 48 hr
treatment period. - Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 172-178 mg/L
- Test temperature:
- 20°C
- pH:
- 7.0-7.9
- Dissolved oxygen:
- 7.7-8.2 mg/L
- Nominal and measured concentrations:
- Nominal= 7.2, 14, 30, 60 and 120 mg/L.
Mean measured (sampling at 0 and 48 hrs) = 6.7, 13, 32, 62 and 130 mg/L. - Details on test conditions:
- Method: flow-through bioassay as described in American Public Health Association and Standard Methods for the Examination of Water and
Wastewater.
A half liter proportional diluter system was used for intermittent introduction of dilution water and MAA into the test chambers. The test system contained six sets of four replicate one liter test chambers designated as control, and level 1 through level 5. The proportional diluter was calibrated preior to use in the test.
Dilution water was a blend of reverse osmosis water and ABC laboratory well water.
10 organisms were assigned to each of the four replicate test chambers (40 Daphnids per concentration).
Water quality measurements were recorded at 0 and 48 hours. - Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 130 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: based on lack of immobilization and or abnormal effects
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 130 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: The 48 hr dose response slope could not be determined because of the lack of an effect level
- Details on results:
- Overall, the measured concentrations represent 101-7.4% of nominal concentrations. Quality control samples analyzed with each sample day over a range of 6.00 to 150 mg/L with recoveries averaging 94+/-19%. Low recovery for the 0 hour sampling was obtained. Duplicate low spikes at teh 48 hour sampling were analyzed to verify the recovery of MAA at the 6.00 mg/l concentration.
Measurement at 0 and 48 hrs of the MAA diluter stock solution averaged 12,000 mg/L which represented 100% of the nominal concentration (12,000 mg/L). - Validity criteria fulfilled:
- yes
- Conclusions:
- In a valid guideline study, the 48 hour EC50 for Daphnia magna was >130 mg/L MAA.
- Executive summary:
In a valid guideline study, the 48 hour EC50 for Daphnia magna was >130 mg/L MAA.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2017-06-20
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- 1. SOFTWARE
OECD Toolbox 3.4.0.17 - Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- - Software tool(s) used including version: QSAR-prediction with QSAR Toolbox 3.4.0.17 Database version: 3.8.8/3.1.2
- GLP compliance:
- no
- Specific details on test material used for the study:
- SMILES: CCCCCCCCOC(=O)C(C)=C
- Test organisms (species):
- Daphnia magna
- Test type:
- other: QSAR predicted value
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 4.79 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- other: QSAR predicted value
- Basis for effect:
- mortality
- Remarks on result:
- other: QSAR predicted value
- Validity criteria fulfilled:
- yes
- Conclusions:
- EC50 (48h) daphnia magna of n-octyl methacrylate predicted by QSAR TOOLBOX 3.4.0.17 database version: 3.8.8/3.1.2 from category trend analysis of 10 category members is 4.79 mg/l.
- Executive summary:
QSAR Toolbox prediction based on trend analysis
Prediction of EC50 (48h) Daphnia magna for n-octyl methacrylate
Summary
Toxicity of the target chemical (4.79 mg/L) is predicted from category members using trend analysis based
on 10 values within the range 2.57 - 380 mg/L from 10 category members. Category members are single
chemicals or mixtures and are selected based on the profile of the target chemical. Only chemicals having
experimental data are listed in the category.
The target chemical FALLS within applicability domain of the prediction. The data used for calculating the current prediction is taken from 11 experimental values selected from
the following database(s):
1. ECHA CHEM
NOTE: Any of data in this dataset are disseminated by the European Union on a right-to-know basis and this is not a publication in the same sense as a book or an article in a journal. The right of ownership in any part of this information is reserved by the data owner(s). The use of this information for any other, e.g. commercial purpose is strictly reserved to the data owners and those persons or legal entities having paid the respective access fee for the intended purpose.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Methodological deficiencies.
- Justification for type of information:
- Read across from an analogous methacrylate ester.
REPORTING FORMAT FOR THE ANALOGUE APPROACH
see attached category document - Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Principles of method if other than guideline:
- OECD Guidelines (1984) Daphnia sp., Acute Immobilisation test and Reproduction test
- GLP compliance:
- no
- Analytical monitoring:
- not specified
- Vehicle:
- yes
- Details on test solutions:
- The test material was dissolved in DMF/Tween 80 and diluted in test medium.
- Test organisms (species):
- Daphnia magna
- Test type:
- not specified
- Water media type:
- not specified
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.32 mg/L
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.85 mg/L
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH
Further information is included as attachment. Please also see attached justification.
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
The constituents of the UVCB substance NUMA (Nonyl-Undecyl methacrylate) are structurally related mono alkyl methacrylate esters differing only in the respective alcoholic moieties. The main proportion of these esters are of the n-type the minor proportion of the iso type. Considering the small amount of iso-types and the negligible differences in (eco-) toxicological properties between the n- and iso types, in this assessment both types of one ester with one specific chain length are assessed together as a whole.
Further information is included as attachment. Please also see attached justification Chapter 1
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
Further information is included as attachment. Please also see attached justification Chapter 1.
3. ANALOGUE APPROACH JUSTIFICATION
Please see attached justification Chapter 1 and 3.
4. DATA MATRIX
Please see attached justification Chapter 1.- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across: supporting information
- Reason / purpose for cross-reference:
- read-across: supporting information
- Reason / purpose for cross-reference:
- read-across: supporting information
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- < 1 mg/L
- Nominal / measured:
- estimated
- Basis for effect:
- mobility
- Remarks on result:
- other: UVCB: LC 50 is estimated from in a worst case approach structural analouge 2-EHMA
- Conclusions:
The LC 50 for the UVCB substance NUMA is predicted to be worst case <1.0 mg/L, leading to the strictest classification under CLP for acute aquatic toxicity.- Executive summary:
There are no test data for any of the constituents and the main proportion of the constituents are in the critical range of C8 -C11 methacrylates for aquatic toxicity, the data are used for a worst case approach. Regardless of the ester size distribution, the LC50for NUMA is assumed to be below 2 -EHMA (2.18 mg/L). For precautionary reasons the LC 50 is predicted to be <1.0 mg/L, leading to the strictest classification under CLP for acute aquatic toxicity. Regarding chronic effects NUMA with its constituents is assessed in analogy to i-DMA which is the worst case (by available data). Considering this very conservative approach, the read across and the assessment are regarded as acceptable with a medium level of confidence.
Referenceopen allclose all
- Measured Concentrations : The test concentrations were
measured at the start and the 48th hour. Some of the test
concentrations were < 80 % of the nominal concentration.
------------------------------------------------------------
Measured Percent of Geometric
concentration (mg/L) Nominal Mean
Nominal during 48 hr
Concentration
---------------------------------------------
mg/L 0 hr 48 hr 0 hr 48 hr (mg/L)
------------------------------------------------------------
Control <0.04 <0.04 -- -- --
Solvent Control <0.04 <0.04 -- -- --
1.00 0.86 0.76 86 76 0.81
1.80 1.73 1.30 96 72 1.50
3.10 2.62 2.34 85 75 2.48
5.50 5.13 4.27 93 78 4.68
9.70 8.56 7.59 88 78 8.06
17.0 15.6 13.1 92 77 14.3
30.0 27.6 25.3 92 84 26.4
------------------------------------------------------------
Mortality or Immobility: No test daphnid was affected at
control, solvent control, 1.00, 1.80 and 3.10 mg/L. All
test daphnids were immobilized at 17.0 and 30.0 mg/L, both at
48th hour. The lowest level where the test daphnids was
immobilized was 5.50 mg/L at the 24th hour.
------------------------------------------------------------
Cumulative Number of Immobilized Daphnids
Nominal (Percent Immobility)
concentration ---------------------------------------------
mg/L 24 hr 48 hr
------------------------------------------------------------
Control 0 ( 0 ) 0 ( 0 )
Solvent Control 0 ( 0 ) 0 ( 0 )
1.00 0 ( 0 ) 0 ( 0 )
1.80 0 ( 0 ) 0 ( 0 )
3.10 0 ( 0 ) 0 ( 0 )
5.50 3 ( 50 ) 12 ( 60 )
9.70 5 ( 25 ) 19 ( 95 )
17.0 11 (55) 20 (100)
30.0 19 (95) 20 (100)
------------------------------------------------------------
- Calculation of toxicity values:: Based on the mean measured
concentrations. The reason is that some of the measured
concentrations were < 80 % of the nominal concentration.
QSAR TOOLBOX 3.4.0.17 (database version: 3.8.8/3.1.2) predicted that n-octyl methacrylate has an EC50 of 4.79 mg/L( Daphnia magna).
Toxicity of the target chemical is predicted from category members using trend analysis based
on 10 values within the range of 2.57 - 380 mg/L from 10 category members. Category members are single
chemicals or mixtures and are selected based on the profile of the target chemical. Only chemicals having
experimental data are listed in the category.
The target chemical FALLS within applicability domain of the prediction.
The data used for calculating the current prediction is taken from 11 experimental values selected from
the following database(s):
1. ECHA CHEM
Description of key information
There are no test data for any of the constituents and the main proportion of the constituents are in the critical range of C8 -C11 methacrylates for aquatic toxicity, the data are used for a worst case approach. Regardless of the ester size distribution, the LC50for NUMA is assumed to be below 2 -EHMA (2.18 mg/L). For precautionary reasons the LC 50 is predicted to be <1.0 mg/L, leading to the strictest classification under CLP for acute aquatictoxicity.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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