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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
As the substance was administered undiluted, it can be expected that the corrosive effects were manifested in the GI tract and the LD50 cannot be attributed solely to systemic toxicity. Very limited documentation of experimental details.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
Standard acute method: strain: Wistar; 8-10 male animals per group, 900-1750 mg/kg undiluted.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Methacrylic acid
EC Number:
201-204-4
EC Name:
Methacrylic acid
Cas Number:
79-41-4
Molecular formula:
C4H6O2
IUPAC Name:
2-methylprop-2-enoic acid
Details on test material:
Methacrylic acid (CAS: 79-41-4)
Purity: 99 % administered undiluted
Supplier: Merck

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
0.9, 1.00, 1.25, 1.50, 1.75 g/kg
No. of animals per sex per dose:
10 males per group at 0.9, 1.00, 1.25 g/kg; 8 males per group at 1.50, 1.75 g/kg
Details on study design:
Animals were observed for 10 days following adminstration of the substance.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
1 320 mg/kg bw
Based on:
test mat.
Mortality:
Dose g/kg Mortality
0.9 0/10
1.00 2/10
1.25 4/10
1.50 6/8
1.75 8/8

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
Using a valid scientific method, the oral LD50 of undiluted MAA to male rats was 1320 mg/kg bw.
Executive summary:

Using a valid scientific method, the oral LD50 of undiluted MAA to male rats was 1320 mg/kg bw.