Sodium iodate

Endpoint summary

Description of key information

The Merck Index, Cosmetic Ingredient review, Lent et al (2017)

The acute oral LD50 of the substance to mice was reported to be 505 mg/kg.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Reference 1

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

not stated

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

secondary literature

Qualifier:

no guideline available

Principles of method if other than guideline:

Groups of 10 fasted female white Swiss mice received test material orally. They were observed for two weeks following dosing and underwent necropsy.
Review references Webster et al. 1957 (Webster SH, Rice ME, Highman B, Von Oettingen WF (1957) The toxicology of potassium and sodium iodates: acute toxicity in mice. J Pharmacol Exp Ther 120: 171-8)

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

no

Specific details on test material used for the study:

- 6 %

Species:

mouse

Strain:

Swiss

Route of administration:

oral: unspecified

No. of animals per sex per dose:

10 females per dose

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes

Key result

Sex:

female

Dose descriptor:

LD50

Effect level:

505 mg/kg bw

Based on:

not specified

Signs of intoxication included diarrhoea, alternate hyperactivity and lassitude, followed by weakness, prostration, and dyspnea. At higher doses, death was often preceded by excitability and convulsions. Haemoglobinuria occurred in many of the animals. Animals that survived 2 weeks following dosing underwent necropsy. At microscopic examination, lesions, such as degeneration of many parietal cells of the gastric glands, were observed in animals dosed with 463 mg/kg test material.

Interpretation of results:

other: Category 4 according to EU criteria

Conclusions:

Under the conditions of the study the acute oral LD50 of the test material to female Swiss mice was 505 mg/kg.

Executive summary:

Groups of 10 fasted female white Swiss mice received test material orally. They were observed for two weeks following dosing and underwent necropsy.

Signs of intoxication included diarrhoea, alternate hyperactivity and lassitude, followed by weakness, prostration, and dyspnea. At higher doses, death was often preceded by excitability and convulsions. Haemoglobinuria occurred in many of the animals. Animals that survived 2 weeks following dosing underwent necropsy. At microscopic examination, lesions, such as degeneration of many parietal cells of the gastric glands, were observed in animals dosed with 463 mg/kg test material.

Under the conditions of the study the acute oral LD50 of the test material to female Swiss mice was 505 mg/kg.

Reference 2

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

not specified

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Qualifier:

no guideline available

Principles of method if other than guideline:

Effects following acute oral exposure to female mice are reported.

GLP compliance:

not specified

Remarks:

GLP compliance not specified in publication

Species:

mouse

Sex:

not specified

Route of administration:

oral: unspecified

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

505 mg/kg bw

Based on:

not specified

Reported effects of sodium iodate and potassium iodate oral exposure included alternate hyperactivity and lassitude, weakness, prostration, dyspnea, and diarrhoea. Transient increases in gastrointestinal pH and degeneration of parietal cells, haemolytic effects including haemoglobinuria and haemosiderin deposits in the kidneys were observed. Mortality was attributed to renal damage.

Interpretation of results:

other: Category 4 according to EU criteria

Conclusions:

The acute oral LD50 of the test material to mice is reported to be 505 mg/kg.

Executive summary:

The acute oral LD50 of the test material to mice is reported to be 505 mg/kg.

Reported effects of sodium iodate and potassium iodate oral exposure included alternate hyperactivity and lassitude, weakness, prostration, dyspnea, and diarrhoea. Transient increases in gastrointestinal pH and degeneration of parietal cells, haemolytic effects including haemoglobinuria and haemosiderin deposits in the kidneys were observed. Mortality was attributed to renal damage.

Reference 3

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

not stated

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

Valid with restrictions. This is peer reviewed data where the test methodology and identity of the substance have been evaluated, and a reliable and representative value for the endpoint has been selected. No information on GLP status or test guideline followed is available.

Qualifier:

no guideline available

Principles of method if other than guideline:

Handbook data does not specify the method. Data from peer reviewed source.

GLP compliance:

not specified

Test type:

other: Handbook data does not specify the method. Data from peer reviewed source.

Species:

mouse

Sex:

female

Route of administration:

oral: unspecified

Key result

Sex:

female

Dose descriptor:

LD50

Effect level:

505 mg/kg bw

Based on:

not specified

Interpretation of results:

other: Category 4 according to EU criteria

Conclusions:

According to the handbook data the acute oral LD50 of the test material to female mice is 505 ± 26 mg/kg.

Executive summary:

According to the handbook data the acute oral LD50 of the test material to female mice is 505 ± 26 mg/kg.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Dose descriptor:

LD50

Value:

505 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

Acute Oral Toxicity

The Merck Index

According to the handbook data the acute oral LD50 of the test material to female mice is 505 ± 26 mg/kg.

Cosmetic Ingredient Review

Groups of 10 fasted female white Swiss mice received test material orally. They were observed for two weeks following dosing and underwent necropsy.

Signs of intoxication included diarrhea, alternate hyperactivity and lassitude, followed by weakness, prostration, and dyspnea. At higher doses, death was often preceded by excitability and convulsions. Hemoglobinuria occurred in many of the animals. Animals that survived 2 weeks following dosing underwent necropsy. At microscopic examination, lesions, such as degeneration of many parietal cells of the gastric glands, were observed in animals dosed with 463 mg/kg test material.

Under the conditions of the study the acute oral LD50 of the test material to female Swiss mice was 505 mg/kg.

Lent et al. (2017)

The acute oral LD50 of the test material to mice is reported to be 505 mg/kg.

Reported effects of sodium iodate and potassium iodate oral exposure included alternate hyperactivity and lassitude, weakness, prostration, dyspnea, and diarrhea. Transient increases in gastrointestinal pH and degeneration of parietal cells, hemolytic effects including hemoglobinuria and hemosiderin deposits in the kidneys were observed. Mortality was attributed to renal damage.

Murray (1953)

The test material was dosed to groups of 10 mice at dose levels of 250, 750 and 2500 mg/kg bw.

No symptoms were reported in the group dosed at 250 mg/kg bw. At the dose level of 750 mg/kg bw 7 of the 10 animals died within 3 weeks. At 2500 mg/kg bw all of the animals died within 12 hours.

Justification for classification or non-classification

In accordance with the criteria for classification as defined in Annex I, Regulation (EC) No 1272/2008, the substance requires classification for acute oral toxicity (category 4) and is assigned the hazard statement "H302: Harmful if swallowed".