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EC number: 201-781-2 | CAS number: 87-89-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Myoinositol. III. Effect of an Excess Dosage of Myoinositol on the Pattern of Lipids in the Liver of Young Rats
- Author:
- Natsume K
- Year:
- 1 965
- Bibliographic source:
- Bitamin, 32(4):363-368
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Male rats were given oral doses of the test substance for 45 days.
- GLP compliance:
- no
Test material
- Reference substance name:
- Myo-inositol
- EC Number:
- 201-781-2
- EC Name:
- Myo-inositol
- Cas Number:
- 87-89-8
- Molecular formula:
- C6H12O6
- IUPAC Name:
- cyclohexane-1,2,3,4,5,6-hexol
- Test material form:
- solid
- Details on test material:
- - Purity: not reported
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 45 days
- Frequency of treatment:
- Daily
Doses / concentrationsopen allclose all
- Dose / conc.:
- 10 mg/kg bw/day (nominal)
- Remarks:
- 20-day old rats for 45 days; 10.0 mg/kg/day is equivalent to 0.5 mg/animal/day
- Dose / conc.:
- 100 mg/kg bw/day (nominal)
- Remarks:
- 20-day old rats for 45 days; 100.0 mg/kg/day is equivalent to 5 mg/animal/day
- Dose / conc.:
- 200 mg/kg bw/day (nominal)
- Remarks:
- 20-day old rats for 45 days; 200.0 mg/kg/day is equivalent to 10 mg/animal/day
- Dose / conc.:
- 1 000 mg/kg bw/day (nominal)
- Remarks:
- 20-day old rats for 45 days; 1000.0 mg/kg/day is equivalent to 50 mg/animal/day
- Dose / conc.:
- 5 mg/kg bw/day (nominal)
- Remarks:
- 3-month-old rats for 1 month
- Dose / conc.:
- 50 mg/kg bw/day (nominal)
- Remarks:
- 3-month-old rats for 1 month
- Dose / conc.:
- 500 mg/kg bw/day (nominal)
- Remarks:
- 3-month-old rats for 1 month
- Dose / conc.:
- 5 000 mg/kg bw/day (nominal)
- Remarks:
- 3-month-old rats for 1 month
- Control animals:
- yes, concurrent vehicle
Examinations
- Other examinations:
- Growth of the animals was determined. Total lipids, total cholesterol and serum in the liver were determined, and urine was analyzed for the test substance.
Results and discussion
Results of examinations
- Clinical signs:
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- effects observed, treatment-related
- Description (incidence and severity):
- Growth for the 20-day old rats administered 0.5 mg/animal/day (the 10 mg/kg/day group) was better than the control group while growth for the 50 mg/animal/day (the 1000 mg/kg/day group) was slightly retarded when compared with the control group. For the 3-month-old rats, no compound-related effects on growth were noted.
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- no effects observed
- Urinalysis findings:
- no effects observed
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Neuropathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- no effects observed
- Histopathological findings: neoplastic:
- not specified
Effect levels
- Dose descriptor:
- other: adverse effects
- Remarks on result:
- other: Administration of the test substance exhibited a favourable effect on the growth rate of rats at doses of 0.5-5 mg/animal/day. Slight growth retardation was observed at 50 mg/animal/day evident 10-15 days after onset of administration.
Target system / organ toxicity
- Critical effects observed:
- no
Applicant's summary and conclusion
- Executive summary:
The effects of the test substance on the weight gain and liver lipid pattern in white rats were investigated. A large dose seemed to inhibit the growth of young animals. The young animals raised on a feed containing a large dose of the test substance showed smaller weight gain than those given feeds containing the standard dosage or sub-standard dosage of the test substance. The administration of the test substance at even larger dose to mature rats produced no growth inhibition. The examination of liver lipid patterns of different groups of animals showed no significant change in the total lipid level or cholesterol level in the liver.
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