p-anisic acid

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

Please refer to the analogue justification attached to IUCLID section 13.

Reason / purpose for cross-reference:

read-across source

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Validity criteria fulfilled:

yes

Conclusions:

No mortality occurred up to 100 mg/L. Therefore the LC50 (96h) was above 100 mg/L and will be reported as >100 mg/L (Oncorhynchus mykiss, OECD 203 and 126, nominal, read-across).

Executive summary:

One experimental study is available investigating the toxicity of the substance to fish. The study was conducted according to OECD 203 (GLP) using the rainbow trout Oncorhynchus mykiss under semi-static conditions. The test was performed according to the threshold approach OECD 126. The absence of mortality at 100 mg/L indicated that fish was not the most sensitive group of test organisms and that the LC50 is greater than the limit test concentration. The measured content of the test item in the fresh as well as in aged test solution was 106% of nominal. Since the content of active ingredient in the samples was between 80 and 120% of nominal, the toxicological endpoints were evaluated using nominal test item concentrations. The LC50 (96 h) of the test item was determined to be > 100 mg/L test item (nominal). The corresponding NOEC (mortality) (96 h) was 100 mg/L test item (nominal). No sublethal effects were observed in the control and test item concentration 100 mg/L after 96 h.

Description of key information

LC50 (96h) >100 mg/L (Oncorhynchus mykiss, OECD 203 and 126, nominal, read-across)

Additional information

No data are available on the acute toxicity to fish of p-anisic-acid (CAS No. 100-09-4). Therefore data from the analogue substance sodium anisate (CAS 536-45-8) were used for read across. This read-across is in accordance with Regulation (EC) No. 1907/2006 Annex XI, 1.5. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment. This read-across is justified in within the analogue justification in IUCLID Section 13.

One experimental study is available investigating the toxicity of the substance to fish. The study was conducted according to OECD 203 (GLP) using the rainbow trout Oncorhynchus mykiss under semi-static conditions. The test was performed according to the threshold approach detailed in OECD 126. The absence of mortality at 100 mg/L indicated that fish was not the most sensitive group of test organisms and that the LC50 is greater than the limit test concentration. The measured content of the test item in the fresh as well as in aged test solution was 106% of nominal. Since the content of active ingredient in the samples was between 80 and 120% of nominal, the toxicological endpoints were evaluated using nominal test item concentrations. The LC50 (96 h) of the test item was determined to be > 100 mg/L test item (nominal). The corresponding NOEC (mortality) (96 h) was 100 mg/L test item (nominal). No sublethal effects were observed in the control and test item concentration 100 mg/L after 96 h.