1-Octanamine, N,N-dimethyl-, N-oxide

Density

Link to relevant study record(s)

Reference

Endpoint:

relative density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

November 1st, 2007 - July 09th, 2008

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.3 (Relative Density)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

pycnometer method

Specific details on test material used for the study:

- Analytical purity: 82.3%
- Purity test date: Not available
- Lot/batch No.: GN-8
- Expiration date of the lot/batch: Not available
- Appearance: Amber coloured, extremely viscous liquid
- Storage: In the dark at room temperature
- Additional information on test material used for the study: It was attempted to purify the substance to a purity of >80% by using an alternative synthetic route, as opposed to the usual commercial route of synthesis which results in a purity of the substance of approximately 40% in water. This alternative synthetic route generated the substance at 82.3% purity, however it also generated an impurity (methanol at 4.0%) which is not present in the commercial substance. Based on the classification and labelling of methanol, it is considered that this additional impurity would not have an influence on any of the endpoints discussed in this dossier other than the acute oral toxicity study. Therefore all studies (including the one covering this endpoint) contained in this dossier (other than the acute oral toxicity study) were conducted on the 82.3% pure substance containing the 4.0% methanol impurity. The acute oral toxicity study has been conducted on the commercially generated substance at a purity of approximately 40% in water.

Key result

Type:

relative density

Density:

0.918

Temp.:

20 °C

Glass tubes were used due to the extremely viscous nature of the test material. The test material was warmed to approximately 40°C prior to use, to ensure it was free of bubbles, before allowing the tubes to equilibrates at the test temperature (20.0 ± 0.5°C).

Measurement	Determination
	1	2
Mass of tube (g) Mass of tube and distilled water at 20.0°C (g) Mass of tube and test material at 20.0°C (g) Density of water at 20.0°C (kg/m^3) Density Relative density	25.6736 63.7851 60.7789 998.20 919.47 0.91949	25.8700 64.0209 60.9271 998.20 917.26 0.91728

Mean relative density: 0.918

Temperature = 20.0°C

Conclusions:

The mean relative density of the test material was determined to be 0.918 at 20.0 ± 0.5°C.

Executive summary:

The relative density of the test material was measured in a GLP-compliant study performed in accordance with EU Method A.3, using the pycnometer method. The mean relative density of the test material was determined to be 0.918 at 20.0 ± 0.5°C.

Description of key information

The relative density of the test material was measured in a GLP-compliant study performed in accordance with EU Method A.3, using the pycnometer method. The mean relative density of the test material was determined to be 0.918 at 20.0 ± 0.5°C.

Key value for chemical safety assessment

Relative density at 20C:

0.918

Additional information

The relative density of the test material was determined in a GLP-compliant study performed in accordance with standard methods, without deviations. The study is considered as reliable (Klimisch 1) and was selected as a key study for the endpoint.