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EC number: 253-634-7 | CAS number: 37697-65-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989-05-10 to 1989-11-22
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1-methyl-N,N',N''-tris(1-methylpropyl)silanetriamine
- EC Number:
- 253-634-7
- EC Name:
- 1-methyl-N,N',N''-tris(1-methylpropyl)silanetriamine
- Cas Number:
- 37697-65-7
- Molecular formula:
- C13H33N3Si
- IUPAC Name:
- {bis[(butan-2-yl)amino](methyl)silyl}(butan-2-yl)amine
- Test material form:
- other: viscous liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Ico rat - OFA.SD. (IOPS Caw)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Iffa-Crédo, France
- Age at study initiation: 6-8 weeks
- Weight at study initiation: 206-250 g
- Fasting period before study: No information.
- Housing: individually in type FI polycarbonate cages.
- Diet (e.g. ad libitum): complete pelleted rat-mouse maintenance diet, ad libitum
- Water (e.g. ad libitum):softened and filtered, ad libitum
- Acclimation period: Seven days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17-25
- Humidity (%): 50 - 91
- Air changes (per hr): At least 10
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- % coverage: approximately 10% of the total body surface area.
- Type of wrap if used: Test article was kept in place by means of a semi-occlusive dressing composed of a perforated adhesive bandage.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Yes, using lukewarm water.
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2.39 ml/kg
- Constant volume or concentration used: yes
- Duration of exposure:
- 24 hours
- Doses:
- 2008 mg/kg bw/day
- No. of animals per sex per dose:
- Five
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 15 minutes after administration of the test substance, at 1, 2 and 4 hours, and then daily for the 14 day observation period. The animals were weighed immediately before application of the test material, then at day 8 and 15.
- Necropsy of survivors performed: yes, on day 15. The abdominal and thoracic cavities were opened and particular attention was paid to the liver, heart, kidneys, lungs and skin of the application area.
- Other examinations performed: clinical signs: changes in the fur, in the treated skin, the eyes, mucous membranes, respiratory system, circulated system, autonomic and central nervous system, as well as somato-motor activity and behaviour. Shivering, convulsions, salivation, diarrhoea, lethargy, sleeping and coma were noted with particular attention. Body weight was recorded before application and at day 8 and 15. - Statistics:
- The body weights of the animals were evaluated, for each sex, calculating the mean of the values obtained, the standard deviation, and the variation coefficient, which indicates the homogeneity of the data. No other statistics performed.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 008 mg/kg bw
- Mortality:
- No deaths.
- Clinical signs:
- There were no changes in behaviour or clinical signs in any of the treated animals.
- Body weight:
- There were no treatment-related effects on body weight.
- Gross pathology:
- There were no macroscopic findings that could be associated with treatment.
- Other findings:
- - Cutaneous examinations: According to the description of the study authors, 'a blackish aspect' of the cutaneous surface to the application area of the test article was noted in all the rats on day 2. Then the presence of superficial eschar formations was noted in all the rats from day 3 onwards and up to the end of the observation period. No presence of oedema was noted during the study.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute dermal toxicity study conducted to OECD TG 402 and in compliance with GLP, the LD50 for 1-methyl-N,N',N''-tris(1-methylpropyl)silanetriamine was >2008 mg/kg bw.
- Executive summary:
SBA 52 was applied, once only, as supplied and at the dose level of 2008 mg/kg bw/day, by the cutaneous route under a semi-occlusive dressing, in the Sprague-Dawley rat (five/sex). Mortality and abnormal clinical signs were noted 15 minutes after application, then at 1, 2 and 4 hours, and then daily for the 14 day study period. All the animals were weighed immediately before the skin application of the test substance, and on day 8 and 15. A necropsy was performed for all the animals after the 14 day study period and the final observation. There were no deaths. A blackish aspect of the cutaneous surface to the application area of the test article was noted in all the rats on day 2. Then the presence of superficial eschar formations was noted in all the rats from day 3 onwards and up to the end of the observation period. No presence of oedema was noted during the study. The LD50 was greater than 2008 mg/kg bw.
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