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EC number: 253-634-7 | CAS number: 37697-65-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10/05/1989 - 13/11/1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- (now deleted)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1-methyl-N,N',N''-tris(1-methylpropyl)silanetriamine
- EC Number:
- 253-634-7
- EC Name:
- 1-methyl-N,N',N''-tris(1-methylpropyl)silanetriamine
- Cas Number:
- 37697-65-7
- Molecular formula:
- C13H33N3Si
- IUPAC Name:
- {bis[(butan-2-yl)amino](methyl)silyl}(butan-2-yl)amine
- Test material form:
- other: colourless liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Ico rat-IFA.SD. (IOPS. Caw)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Iffa-Credo, France
- Age at study initiation: 5-7 weeks old
- Weight at study initiation: 120-161 g
- Fasting period before study: 17-18 hours of water only regime
- Housing: housed by sex in groups of 5 in type MI polycarbonate cages
- Diet (e.g. ad libitum): complete pelleted rat-mouse maintenance diet, ad libitum
- Water (e.g. ad libitum): softened and filtered mains water ad libitum
- Acclimation period: 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-25
- Humidity (%): 45-70 % R.H.
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 1781 mg/kg
- Doses:
- 1126 mg/kg, 1411 mg/kg, 1781 mg/kg, 1260 mg/kg, 1596 mg/kg
- No. of animals per sex per dose:
- 5 males and 5 females - 1126 mg/kg
5 males and 5 females - 1411 mg/kg
5 males and 5 females - 1781 mg/kg
5 males and 5 females - 1260 mg/kg
5 males and 5 females - 1596 mg/kg - Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: deaths and abnormal clinical signs were noted 15 min after the administration of the test article, then at 1, 2 and 4 hours and then daily for the 14-day study period; the animals were weighed the day before the treatment, immediately before the treatment and at day 8 and 15 during the study period, and at the time of death from day 2 onwards.
- Necropsy of survivors performed: The animals that died during the study were necropsied as well as the surviving animals at the end of the 14-day study, which were killed by the means of overdosing with carbon dioxide.
- Other examinations performed: after necropsy the abdominal and thoracic cavities were opened and special attention was paid to the liver, heart, lungs and kidneys.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 292 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Bliss' method
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 280 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Litchfield and Wilcoxon' method
- Mortality:
- 10% of the animals in the group treated with 1126 mg/kg died from day 2 onwards. 60% of the rats treated with 1260 mg/kg died from day 2 onwards. 60 % of the rats treated with 1411 mg/kg died from day 2 onwards. 100 % from the rats treated with 1596 mg/kg and 1781 mg/kg died from 2 onwards.
- Clinical signs:
- Subdued behaviour or prostration were noted in all the groups of animals at 2 and 4 hours after administration. Lethargy was observed in the animals treated with 1260 mg/kg or 1596 mg/kg. The surviving animals treated with 1126 mg/kg had normal behaviour by day 2 after administration, while the rats treated with 1260mg/kg or 1411mg/kg had normal behaviour by day 6. One of the surviving animals had diarrhorea (day 4 and 5) from the group treated with 1260 mg/kg and an animal treated with 1411 mg/kg showed piloerrection (day 3, 4 and 5).
- Body weight:
- Males treated with 1781 mg/kg and females treated with 1411mg/kg showed noticeably lower body weight than those in the control group. Males treated with 1411 mg/kg showed statistically lower mean body weight than those in the control group. The rest of the animals did not show any noticeable change in their body weight.
- Gross pathology:
- Animals that died during the study showed congested areas in the lungs, the stomach and the intestines. The animals examined at the end of the study showed adhesion between the liver, the stomach and the abdominal wall.
Any other information on results incl. tables
LD 50 for males:
Bliss' method: 1309 mg/kg
Litchfield and Wilcoxon's method: 1277 mg/kg
LD 50 for females:
Bliss' method: 1275 mg/kg
Litchfield and Wilcoxon' method: 1299 mg/kg
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- In an acute oral toxicity study conducted to the now deleted OECD 401 and to GLP, the LD50 for 1-Methyl-N,N',N''-tris(1-methylpropyl)silanetriamine was 1292 mg/kg bw (Bliss' method) or 1280 mg/kg bw (Litchfield and Wilcoxon's method) in rats.
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