1,2-benzisothiazol-3(2H)-one

Water solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

Not reported

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

Cited as Directive 92/69/EEC, A.6

GLP compliance:

yes

Type of method:

flask method

Water solubility:

4.419 g/L

Temp.:

20.1 °C

pH:

9

Remarks on result:

other: The typical pH value of the samples was 7.6

Water solubility:

1.695 g/L

Temp.:

20.1 °C

pH:

7

Remarks on result:

other: The typical pH value of the samples was 6.9

Water solubility:

1.108 g/L

Temp.:

20.1 °C

Remarks on result:

other: Unadjusted distilled water. The typical pH value of the samples was 5.0

Details on results:

pH effects: Unadjusted, pH 7 and pH 9 were tested.

Conclusions:

The water solubility was determined in unadjusted distilled water, pH 7 buffer and pH 9 buffer. The results were 1.108 g/L at 20.1°C, 1.695 g/L at 20.1°C and 4.419 g/L at 20.1°C respectively.

Executive summary:

Unadjusted distilled water:

1.108 g/L at 20.1°C.

Distilled water buffered at pH 7:

1.695 g/L at 20.1°C.

Distilled water buffered at pH 9:

4.419 g/L at 20.1°C.

Reference 2

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

19 January 2000 to 17 March 2000

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

Cited as Directive 92/69/EEC, A.6

GLP compliance:

yes

Type of method:

flask method

Water solubility:

1 153 mg/L

Temp.:

20 °C

Remarks on result:

other: Distilled water

Water solubility:

810 mg/L

Temp.:

10 °C

pH:

5

Water solubility:

1 113 mg/L

Temp.:

20 °C

pH:

5

Water solubility:

1 631 mg/L

Temp.:

30 °C

pH:

5

Water solubility:

1 301 mg/L

Temp.:

10 °C

pH:

7

Water solubility:

1 707 mg/L

Temp.:

20 °C

pH:

7

Water solubility:

2 438 mg/L

Temp.:

30 °C

pH:

7

Water solubility:

3 181 mg/L

Temp.:

10 °C

pH:

9

Water solubility:

3 628 mg/L

Temp.:

20 °C

pH:

9

Water solubility:

4 220 mg/L

Temp.:

30 °C

pH:

9

Details on results:

Temperature effects: Temperature range of 10 °C to 30 °C

Conclusions:

The water solubility was determined in distilled water at 20°C and pH 5.0, 7.0 and 9.0 aqueous buffer at 10, 20 and 30°C.
The water solubility in distilled water was determined to be 1153 mg/L at 20°C

Executive summary:

The water solubility in distilled water was determined to be 1153 mg/L at 20°C

Reference 3

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

16 September 1998 to 19 November 1998

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

Cited as Directive 92/69/EEC, A.6

GLP compliance:

yes

Type of method:

flask method

Key result

Water solubility:

1 085 mg/L

Conc. based on:

test mat.

Incubation duration:

ca. 24 h

Temp.:

20 °C

pH:

ca. 4.5

Remarks on result:

other: The mixtures were centrifuged and filtered prior to dilution and HPLC determination

The water solubility of BIT was determined to be 1.085 g/L with a relative standard  deviation of 0.92%.

Conclusions:

The water solubility of BIT was determined to be 1085 mg/L with a relative standard deviation of 0.92%.

Executive summary:

The water solubility of BIT was determined to be 1085 mg/L.

Reference 4

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

25 February 2002 to 22 March 2002

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

Cited as Directive 92/69/EEC, A.6

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Key result

Water solubility:

0.727 g/L

Temp.:

10 °C

pH:

4.8

Key result

Water solubility:

0.938 g/L

Temp.:

20 °C

pH:

4.8

Key result

Water solubility:

1.196 g/L

Temp.:

30 °C

pH:

4.8

Key result

Water solubility:

1.288 g/L

Temp.:

20 °C

pH:

6.7

Key result

Water solubility:

1.651 g/L

Temp.:

20 °C

pH:

9.1

Conclusions:

The solubility of BIT over the pH range 4.8 to 9.1 (at 20°C) and temperature range 10 - 30°C (at pH 4.8) increased from 0.938 to 1.651 g/l and 0.727 to 1.196 g/l respectively.

Executive summary:

The water solubility of BIT was 0.727, 0.938, and 1.196 g/l at 10, 20 and  30°C, respectively (pH 4.8).

The water solubility of BIT was 0.938, 1.288, and 1.651 g/l at pH 4.8,  6.7 and 9.1, respectively (20°C).

Description of key information

The water solubility was determined according to EU Method A.6 (Seal, 2002).

Key value for chemical safety assessment

Water solubility:

1 288 mg/L

at the temperature of:

20 °C

Additional information

The water solubility value was measured at pH 6.7.