Registration Dossier
Registration Dossier
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EC number: 215-709-2 | CAS number: 1344-81-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Remarks:
- Tessenderlo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Guideline:
- other: EPA FIFRA Guideline ( Pesticide Assessment Guidelines Subsection F 1982)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Calcium sulfide (Ca(Sx))
- EC Number:
- 215-709-2
- EC Name:
- Calcium sulfide (Ca(Sx))
- Cas Number:
- 1344-81-6
- Molecular formula:
- CaSx (X=2,3,4,5,6,7)
- IUPAC Name:
- Calcium sulfide (Ca(Sx)
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Elkhorn Rabbitry Watsonville, CA
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- not specified
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml undiluted
- Duration of treatment / exposure:
- 4 h / exposure
- Observation period:
- 72 h
- Number of animals:
- 6
- Details on study design:
- See it in page 10th of the attachement. ( procedure part)
Results and discussion
In vivo
Results
- Irritation parameter:
- erythema score
- Remarks:
- 1
- Basis:
- animal #2
- Time point:
- other: 48h and 72 h
- Score:
- ca. 1
- Max. score:
- 1
- Reversibility:
- not specified
- Remarks on result:
- probability of weak irritation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- This compound produced slight temporary irrtation to the skin. Erythema score of 1were observed in 2 out of 6 rabbits at 48 and 72 hours.
- Executive summary:
It is not skin irritant, based on this test, but the CLP harmonised classification found it as a Skin irritant category 2 (H315), so the recommendation is to classify it as a skin irritant Cat 2 (H335).
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