Registration Dossier
Registration Dossier
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EC number: 215-709-2 | CAS number: 1344-81-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Remarks:
- Tessenderlo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Calcium sulfide (Ca(Sx))
- EC Number:
- 215-709-2
- EC Name:
- Calcium sulfide (Ca(Sx))
- Cas Number:
- 1344-81-6
- Molecular formula:
- CaSx (X=2,3,4,5,6,7)
- IUPAC Name:
- Calcium sulfide (Ca(Sx)
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- See it in the attachement on page 7 in the procedure
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 100-5000 mg/kg of body weight
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- See it in the attachement.
- Statistics:
- Lithcfield, J. Jr., and Wilcoxon, F.J. Pharm. Exp. Therap. 96: 99-115 (1949)
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- >= 920 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 773 - < 1 095
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- >= 820 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 773 - < 1 095
- Mortality:
- See it in the attachement on page 8 in the mortality summary table
- Clinical signs:
- other: See it in the attachement on page 7 in the results
- Gross pathology:
- See it in the attachement on page 7 in the results
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- It is classified as H302 ( acuter oral toxicity category 4)
- Executive summary:
LD 50 is 820 mg/kg bw.
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